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Charles River and Aitia Enter Strategic Agreement to Utilize Logica in Discovery Programs for Neurodegenerative Diseases and Oncology
- Strategic partnership includes co-development of patient-derived xenograft (PDX) Digital Twins for in vivo oncology research
Charles Riverto make an equity investment in Aitia as part of the agreement
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Under the terms of the agreement, Aitia will deploy Logica across their portfolio of novel drug targets with the aim of creating and advancing drug candidates for neurological indications, including Alzheimer’s, Parkinson’s, and Huntington’s diseases and cancers, including prostate cancer and multiple myeloma. According to the
“Unraveling the complex genetic and molecular circuitry of neurodegenerative disorders is critical to the discovery of treatments that significantly slow or reverse these devastating diseases,” said
“Combining Aitia’s Digital Twins with Logica’s next-generation solution stands to transform the discovery and development of novel therapeutics for neurological diseases and oncology,” said Professor
Digital Twins: Increasing Translation Through Data
Additionally, Charles River and Aitia have signed a strategic partnership agreement, focused on the development of a patient-derived xenograft (PDX) Digital Twin to predict the best tumor models for in vivo oncology research. The partnership will combine Charles River’s robust, fully-characterized, disease-relevant PDX data and expertise with Aitia’s industry-leading Digital Twin technology to develop PDX Digital Twins in several cancer types. As part of the partnership, Charles River has made an equity investment in Aitia.
In drug discovery, Digital Twins enable the accurate simulation of gene and protein knockdowns at the individual patient level across patient cohorts to discover and genetically validate novel drug targets. This concept can be applied in a similar way to individual tumor types to design more targeted preclinical studies for oncology research. Digital Twins enable the simulation of disease progression and drug response for existing drug candidates to discover biomarkers to better select existing therapies and effective combination therapies.
The Strength of Logica, an Integrated AI Program
“Logica has optimized drug discovery,” said
Logica utilizes industry-leading predictive models, chemical design, and synthesis capabilities, DNA-encoded libraries, in silico high throughput screening from Valo’s Opal Computational Platform as well as Charles River’s leading capabilities in all aspects of discovery optimization including high throughput screening, medicinal chemistry, ADME, biology, pharmacology, and ultimately safety testing and IND submission, joining together for the first time to create a computation-powered, unified target-to-candidate offering.
Last year, Charles River and Flagship’s Pioneering Medicines announced an agreement to deploy Logica across a portfolio of targets with the aim of creating optimized small molecules that lead to novel therapies for unmet medical needs. More recently, Charles River and Related Sciences announced a multi-program collaboration to apply Logica across several previously undrugged targets.
Aitia is the leader in the development and application of Causal AI and Digital Twins to discover the next generation of therapies for neurodegenerative diseases and oncology. By leveraging the convergence of multi-omic patient data, high-performance computing, and causal learning and AI, Aitia is revealing the hidden circuitry of human biology to identify novel targets driving disease and focused patient recruitment for clinical development. Aitia has translated those insights into its Gemini Digital Twins (computational representations of disease), which the company is using to discover new breakthrough therapies. Aitia’s partners include six of the top ten pharmaceutical companies, leading academic research and medical centers, medical societies, leading multi-omic data companies, and patient advocacy groups globally. For more information, please visit www.aitiabio.com.
About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients
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