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Behind every patient stands thousands of scientists and researchers collaborating to develop life-saving drugs. Jenne’s story highlights the importance of that work.
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The contract extension covers multidisciplinary services from across Charles River’s portfolio, including:
- Integrated biology and chemistry capabilities
- Complex primary neuronal assay development
- High-content and fragment-based screening
- Computational chemistry
- Absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetics (PK)
- Protein crystallography
- Extensive in vivo pharmacology approaches in research models for translational assessment
Over their 14-year collaboration, Charles River has established and validated tools and methodologies within expert teams to support CHDI’s mission of developing novel therapeutics that will substantially improve the lives of those affected by HD.
Together, Charles River and CHDI have identified novel potential drug targets, bred and validated translational research animal models, run large screens and generated proof-of-concept molecules, and evaluated the potential efficacy of both small molecule and biologic candidates in preclinical models of HD. These cutting-edge approaches have resulted in over one hundred co-authored posters and dozens of peer-reviewed papers. Additionally, the expertise developed throughout this partnership has helped more broadly facilitate increased HD research within the larger drug discovery and development community.
“Our longstanding partnership with CHDI is built on our mutual
commitment to developing novel therapies for Huntington’s disease. As
an organization, our work with CHDI has led to a much larger
commitment to support the HD research community, through investments
in methodologies, tools and personnel dedicated to this rare disease.”
Birgit Girshick, Corporate Executive Vice President, Discovery & Safety Assessment, Biologics Testing Solutions, and Avian Vaccine Services at Charles River
“Charles River’s early drug discovery team has continuously delivered
scientific expertise that enables our drug discovery research to
produce more efficient results. We are excited to continue our
research and work toward delivering a meaningful treatment to
patients.” –Robi Blumenstein, President,
CHDI Management, Inc.
- “We are continuously inspired by CHDI’s open approach to sharing knowledge and transferring expertise. Our researchers take their work very personally—they are acutely aware of its potential impact—and focus on honing their skills and learning new techniques to help progress HD research forward.” –Outi Kontkanen, Senior Director of Alliance Management at Charles River
About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.
Corporate Vice President, Investor Relations
Corporate Vice President, Public Relations