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The Consortium invests in academic led research projects, typically 2-3 years in duration, which aim to provide validation of targets for the treatment of dementia or explore the tractability of the target for drug discovery. Projects already funded include, among others: novel small molecule inhibitors of the NLRP3 inflammasome, inhibitors of the interaction between key proteins involved in the proliferation of microglia, and the role of immune system regulators and receptors in neurodegeneration. Applications for innovative new dementia targets are now being accepted by Alzheimer’s Research UK in the second phase of the
As the latest contract research organization (CRO) partner chosen by Alzheimer’s Research UK to join the Consortium, Charles River scientists will collaborate with grant recipients, on selected projects, consulting on areas including: biological assay development and screening, high-throughput screening and medicinal chemistry. Grant holders will have regular project review meetings with members of the
“We see an incredible need to research innovative solutions to neurodegenerative diseases.
The Dementia Consortiumbrings together the best minds from academia and industry to progress candidates through the drug discovery and development process. We are proud to be part of the important work they’re doing” –Birgit Girshick, Corporate Executive Vice President, Discovery & Safety Assessment, Biologics Testing Solutions, and Avian Vaccine Services, Charles River
- “Dementia impacts nearly 50 million people worldwide, a number that is expected to triple by 2050. Treating dementia poses an enormous medical challenge, and we are excited to leverage Charles River’s early drug discovery expertise in our effort to tackle it.” –Carol Routledge, PhD, Director of Research, Alzheimer’s Research UK
About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.
Corporate Vice President, Investor Relations
Corporate Vice President, Public Relations