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Charles River Laboratories Showcases End-to-End Oncology Capabilities at AACR 2023
Researchers highlight the importance of next-generation technologies as strategic tools for drug discovery
Charles River’s team of industry-leading oncology experts have contributed to 84 percent of the cancer therapies approved by the
Navigating Cell Therapy Discovery and Development
Cell therapies continue to be a focus in the field of advanced therapies. During a Spotlight Session, scientific leaders from across disciplines will discuss cell therapy discovery and development, including insights into the discovery journey from materials, research models, and quality assessment, as well as considerations and capabilities to streamline research and mitigate self-inflicted risks.
Tuesday, April 18, 3:00-4:00 p.m., Theater A: Navigating Cell Therapy Discovery and Development, featuring:
Nicholas Ostrout, Senior Advisor Cell & Gene Therapy
Arif Khan, Senior Scientist Lead
- Gemma Moiset, Group Leader Advanced Modalities
Steven Bronson, Scientific Product Manager
Utilizing Technology to Fuel Discovery Innovation
Mutation-targeting therapies have become a new paradigm for cancer treatment. In a joint poster presentation, Charles River and
Monday, April 17, 9:00 a.m.-12:30 p.m., Section 20: KRAS, BRAF, BRCA1 and EGFR Mutation-Specific Panels using Hydrogel-Based 3D in vitro Tumor Models
Identifying how to optimally combine immunotherapies with other available anti-cancer therapies is a major challenge in oncology. In
Tuesday, April 18, 1:30-5:00 p.m., Section 21: Transcriptomic Analysis in a Renal Cancer PDX Model Enables the Deconvolution of Additive and Synergistic Effects of the Six Different Standard of Care Compounds with Anti-PD-1 Treatment
Lastly, the increased use of machine learning (ML) in drug discovery has allowed medicinal chemists to operate at a vastly different scale than traditional approaches by enabling them to search much larger universes of potential compounds. In 2022,
A full schedule of Charles River’s activities during AACR 2023, as well was reprints of each poster, are available online. Charles River experts will be available for meetings to discuss how an integrated approach can support drug discovery and development programs from hit identification to IND (Investigational New Drug) filing.
Throughout the conference, Charles River will be providing live updates on the
“Cancer is the second leading cause of death worldwide, and patients are relying on the research and development of new therapeutics. AACR offers our researchers a unique opportunity to learn from leaders in the industry and share critically important knowledge to further innovation.” –
Aidan Synnott, Corporate Vice President, Global Discovery Services, Charles River
"Logica integrates world-leading laboratory capabilities with best-in-class AI-driven molecular design. The offering is packaged in a unique, success-based pricing model that produces a development candidate that is ~50% less expensive than alternatives. Given the breadth of Logica's capabilities, we are confident that the molecules we deliver will be considerably better than what can be provided by other offerings. It’s a win-win.” –Guido Lanza, Senior Vice President, and Logica General Manager,
“Kibur Medical provides drug developers with the unique ability to simultaneously profile in situ anti-tumor activity of up to 20 unique agents or combinations independently. This deep molecular insight into in vivo tumor-drug pharmacodynamics significantly accelerates and de-risks oncology drug development and precision medicine.” – Professor
Oliver Jonas, co-Founder, Kibur Medical Inc.
"Cypre 3D Tumor Panels offer PDX IC50 data in 30 days. Leveraging the Cypre hydrogel patterning technology, targeted- and immuno-therapeutic leads of various modalities (small molecules, antibodies, and cell therapy) are screened against proprietary 3D in vitro models of the tumor microenvironment using high content image analysis. We look forward to serving our clients with our pre-configured Cypre Tumor Panel Catalog." –
Kolin C. Hribar, PhD, CEO & Founder, Cypre Inc.
About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.
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Corporate Vice President, Investor Relations
Corporate Vice President, Public Relations