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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 24, 2011	Sep. 25, 2010	Sep. 24, 2011	Sep. 25, 2010
Net sales related to products	$ 116,932	$ 108,684	$ 361,069	$ 345,068
Net sales related to services	160,647	162,201	490,616	506,696
Total net sales	277,579	270,885	851,685	851,764
Costs and expenses
Cost of products sold	66,368	62,176	197,405	188,553
Cost of services provided	118,495	118,209	352,606	371,756
Selling, general and administrative	50,345	48,005	152,561	176,562
Termination fee		30,000		30,000
Amortization of intangibles	5,277	6,027	16,454	18,246
Operating income	37,094	6,468	132,659	66,647
Other income (expense)
Interest income	138	243	1,060	857
Interest expense	(11,944)	(12,641)	(32,619)	(25,753)
Other, net	(747)	(1,648)	(1,092)	(2,850)
Income from continuing operations before income taxes	24,541	(7,578)	100,008	38,901
Provision for income taxes	5,630	16,670	11,564	30,577
Income (loss) from continuing operations, net of tax	18,911	(24,248)	88,444	8,324
Loss from discontinued operations, net of tax	(18)	(986)	(5,695)	(2,463)
Net income (loss)	18,893	(25,234)	82,749	5,861
Less: Net (income) loss attributable to noncontrolling interests	(95)	293	(298)	1,034
Net income (loss) attributable to common shareowners	$ 18,798	$ (24,941)	$ 82,451	$ 6,895
Basic:
Continuing operations (in dollars per share)	$ 0.38	$ (0.38)	$ 1.71	$ 0.15
Discontinued operations (in dollars per share)		(0.02)	(0.11)	(0.04)
Net income (loss) attributable to common shareowners (in dollars per share)	0.38	(0.40)	1.60	0.11
Diluted:
Continuing operations (in dollars per share)	0.37	(0.38)	1.69	0.14
Discontinued operations (in dollars per share)		(0.02)	(0.11)	(0.04)
Net income (loss) attributable to common shareowners (in dollars per share)	$ 0.37	$ (0.40)	$ 1.58	$ 0.11

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 24, 2011	Dec. 25, 2010
Current assets
Cash and cash equivalents	$ 81,220	$ 179,160
Trade receivables, net	202,379	192,972
Inventories	94,391	100,297
Other current assets	78,339	80,465
Total current assets	456,329	552,894
Property, plant and equipment, net	728,887	752,657
Goodwill, net	199,799	198,438
Other intangibles, net	105,941	121,236
Deferred tax asset	37,364	45,003
Other assets	57,053	63,145
Total assets	1,585,373	1,733,373
Current liabilities
Current portion of long-term debt and capital leases	19,838	30,582
Accounts payable	34,622	30,627
Accrued compensation	44,139	48,918
Deferred revenue	54,570	66,905
Accrued liabilities	56,565	59,369
Other current liabilities	14,108	23,379
Total current liabilities	223,842	259,780
Long-term debt and capital leases	720,483	670,270
Other long-term liabilities	99,679	114,596
Total liabilities	1,044,004	1,044,646
Commitments and contingencies
Shareowners' equity
Preferred stock, $0.01 par value; 20,000,000 shares authorized; no shares issued and outstanding
Common stock, $0.01 par value; 120,000,000 shares authorized; 78,477,546 issued and 49,723,708 shares outstanding at September 24, 2011 and 77,531,056 issued and 56,441,081 shares outstanding at December 25, 2010	785	775
Capital in excess of par value	2,051,777	1,996,874
Accumulated deficit	(492,711)	(575,162)
Treasury stock, at cost, 28,753,838 shares and 21,089,975 shares at September 24, 2011 and December 25, 2010, respectively	(1,046,119)	(768,699)
Accumulated other comprehensive income	25,979	33,635
Total shareowners' equity	539,711	687,423
Noncontrolling interests	1,658	1,304
Total equity	541,369	688,727
Total liabilities and equity	$ 1,585,373	$ 1,733,373

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Sep. 24, 2011	Dec. 25, 2010
CONDENSED CONSOLIDATED BALANCE SHEETS
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	20,000,000	20,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	120,000,000	120,000,000
Common stock, shares issued	78,477,546	77,531,056
Common stock, shares outstanding	49,723,708	56,441,081
Treasury stock, shares	28,753,838	21,089,975

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 24, 2011	Sep. 25, 2010
Cash flows relating to operating activities
Net income	$ 82,749	$ 5,861
Less: Loss from discontinued operations	(5,695)	(2,463)
Income from continuing operations	88,444	8,324
Adjustments to reconcile net income from continuing operations to net cash provided by operating activities:
Depreciation and amortization	64,249	69,990
Non-cash compensation	16,919	21,283
Amortization of debt issuance costs and discounts	15,229	15,658
Other, net	(1,350)	3,823
Changes in assets and liabilities:
Trade receivables	(8,467)	(22,601)
Inventories	7,090	1,804
Other assets	1,834	(7,523)
Accounts payable	459	3,327
Accrued compensation	(5,143)	1,015
Deferred revenue	(12,400)	(9,224)
Accrued liabilities	(3,730)	10,898
Taxes payable and prepaid taxes	(21,196)	9,422
Other liabilities	(6,993)	(5,427)
Net cash provided by operating activities	134,945	100,769
Cash flows relating to investing activities
Capital expenditures	(21,672)	(26,853)
Purchases of investments	(19,837)	(26,603)
Proceeds from sale of investments	27,840	67,467
Other, net	1,620	572
Net cash provided by (used in) investing activities	(12,049)	14,583
Cash flows relating to financing activities
Proceeds from long-term debt and revolving credit agreement	235,806	577,834
Payments on long-term debt, capital lease obligation and revolving credit agreement	(214,299)	(364,782)
Proceeds from exercises of stock options	20,574	3,118
Purchase of treasury stock and Accelerated Stock Repurchase Program	(255,610)	(356,421)
Other, net	(2,248)	(13,289)
Net cash used in financing activities	(215,777)	(153,540)
Discontinued operations
Net cash (used in) provided by operating activities	(1,703)	653
Net cash provided by investing activities		2,799
Net cash provided by (used in) discontinued operations	(1,703)	3,452
Effect of exchange rate changes on cash and cash equivalents	(3,356)	(10,405)
Net change in cash and cash equivalents	(97,940)	(45,141)
Cash and cash equivalents, beginning of period	179,160	182,574
Cash and cash equivalents, end of period	81,220	$ 137,433
Supplemental cash flow information
Capitalized interest	$ 202

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY - USD ($) $ in Thousands	Total	Accumulated Deficit	Accumulated Other Comprehensive Income	Common Stock	Capital in Excess of Par	Treasury Stock	Noncontrolling Interest	Comprehensive Income
Balance at Dec. 26, 2009	$ 1,373,824						$ (1,419)
Components of comprehensive income, net of tax:
Net income	5,861						(1,034)	$ 5,861
Foreign currency translation adjustment	(9,899)						(81)	(9,899)
Amortization of pension, net gain/loss and prior service cost	260							260
Unrealized loss on marketable securities	775							775
Total comprehensive income	(3,003)						(1,115)	(3,003)
Tax detriment associated with stock issued under employee compensation plans	(538)
Issuance of stock under employee compensation plans	3,133
Acquisition of treasury shares	(254,998)
Accelerated Stock Repurchase equity instrument	(101,423)
Stock-based compensation	21,443
Balance at Sep. 25, 2010	1,038,168						(2,804)
Balance at Dec. 25, 2010	688,727	$ (575,162)	$ 33,635	$ 775	$ 1,996,874	$ (768,699)	1,304
Components of comprehensive income, net of tax:
Net income	82,749	82,451					298	82,749
Foreign currency translation adjustment	(7,778)		(7,834)				56	(7,778)
Amortization of pension, net gain/loss and prior service cost	483		483					483
Unrealized loss on marketable securities	(305)		(305)					(305)
Total comprehensive income	75,149						354	$ 75,149
Tax detriment associated with stock issued under employee compensation plans	(1,110)				(1,110)
Issuance of stock under employee compensation plans	20,478			10	20,468
Acquisition of treasury shares	(244,654)				32,766	(277,420)
Accelerated Stock Repurchase equity instrument	(14,140)				(14,140)
Stock-based compensation	16,919				16,919
Balance at Sep. 24, 2011	$ 541,369	$ (492,711)	$ 25,979	$ 785	$ 2,051,777	$ (1,046,119)	$ 1,658

Basis of Presentation

9 Months Ended

Sep. 24, 2011

Basis of Presentation

Basis of Presentation

1. Basis of Presentation

The condensed consolidated interim financial statements are unaudited, and certain information and footnote disclosures related thereto normally included in financial statements prepared in accordance with generally accepted accounting principles in the United States of America have been omitted in accordance with Rule 10-01 of Regulation S-X. In the opinion of management, the accompanying unaudited condensed consolidated financial statements were prepared following the same policies and procedures used in the preparation of the audited financial statements and reflect all adjustments (consisting of normal recurring adjustments) considered necessary to state fairly the financial position and results of operations of Charles River Laboratories International, Inc. The results of operations for the interim periods are not necessarily indicative of the results for the entire fiscal year. These condensed consolidated financial statements should be read in conjunction with our Annual Report on Form 10-K for the year ended December 25, 2010.

Certain amounts in prior-year financial statements and related notes have been reclassified to conform with the current year presentation.

- Definition

The entire disclosure for organization, consolidation and basis of presentation of financial statements disclosure.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 2-6
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Name Statement of Position (SOP)
-Publisher AICPA
-Number 94-6
-Paragraph 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Name FASB Interpretation (FIN)
-Publisher FASB
-Number 46R
-Paragraph 4, 14, 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
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+ Details

Restructuring and Contract Termination Costs

9 Months Ended

Sep. 24, 2011

Restructuring and Contract Termination Costs

Restructuring and Contract Termination Costs

2. Restructuring and Contract Termination Costs

We implemented headcount reductions to improve operating efficiency and profitability at various sites. As of September 24, 2011, we had accrued severance and retention costs related to these actions of $4,350 in our consolidated balance sheets, of which $1,932 was included in accrued compensation and $2,418 in other long-term liabilities on our consolidated balance sheet related to these actions.

During the first nine months of 2011, we recorded severance charges of $1,317 related primarily to further headcount reductions, of which $437 is included in cost of sales and $880 in selling, general and administrative expense. Additionally, we recorded contract termination costs of $970 during the nine months ended September 24, 2011.

		Nine Months Ended

Severance and Retention Costs		September 24, 2011			September 25, 2010
Beginning balance		$	10,658		$	4,332
Expense			1,317			5,571
Payments/utilization			(7,625	)		(6,317	)

	Ending balance	$	4,350		$	3,586

- Definition

The entire disclosure for restructuring and related activities. Description of restructuring activities such as exit and disposal activities, include facts and circumstances leading to the plan, the expected plan completion date, the major types of costs associated with the plan activities, total expected costs, the accrual balance at the end of the period, and the periods over which the remaining accrual will be settled.

+ References + Details

Supplemental Balance Sheet Information

9 Months Ended

Sep. 24, 2011

Supplemental Balance Sheet Information

Supplemental Balance Sheet Information

3. Supplemental Balance Sheet Information

The composition of net trade receivables is as follows:

		September 24, 2011			December 25, 2010

Customer receivables		$	176,257		$	170,696
Unbilled revenue			30,482			27,095

Total			206,739			197,791
Less allowance for doubtful accounts			(4,360	)		(4,819	)

	Net trade receivables	$	202,379		$	192,972

The composition of inventories is as follows:

		September 24, 2011		December 25, 2010

Raw materials and supplies		$	12,715	$	13,153
Work in process			16,624		13,869
Finished products			65,052		73,275

	Inventories	$	94,391	$	100,297

The composition of other current assets is as follows:

		September 24, 2011		December 25, 2010

Prepaid assets		$	20,889	$	21,434
Deferred tax asset			28,521		31,251
Marketable securities			6,188		9,834
Prepaid income tax			22,512		13,856
Restricted cash			229		228
Current assets of discontinued businesses			—		3,862

	Other current assets	$	78,339	$	80,465

The composition of net property, plant and equipment is as follows:

		September 24, 2011			December 25, 2010

Land		$	40,610		$	40,409
Buildings			695,480			694,342
Machinery and equipment			345,706			327,353
Leasehold improvements			30,418			26,772
Furniture and fixtures			10,639			10,473
Vehicles			5,475			5,456
Computer hardware and software			105,976			106,073
Construction in progress			44,845			45,465

	Total		1,279,149			1,256,343
Less accumulated depreciation			(550,262	)		(503,686	)

Net property, plant and equipment		$	728,887		$	752,657

Depreciation is calculated using a straight-line method based on estimated useful lives of the assets. Depreciation expense for the nine months ended September 24, 2011 and September 25, 2010 was $47,795 and $51,744, respectively.

The composition of other assets is as follows:

		September 24, 2011		December 25, 2010

Deferred financing costs		$	10,263	$	11,167
Cash surrender value of life insurance policies			24,174		31,054
Long-term marketable securities			11,070		11,377
Other assets			10,425		8,725
Long-term assets of discontinued businesses			1,121		822

	Other assets	$	57,053	$	63,145

The composition of other current liabilities is as follows:

		September 24, 2011		December 25, 2010

Accrued income taxes		$	8,416	$	18,372
Current deferred tax liability			1,071		963
Accrued interest and other			3,492		760
Current liabilities of discontinued businesses			1,129		3,284

	Other current liabilities	$	14,108	$	23,379

The composition of other long-term liabilities is as follows:

		September 24, 2011		December 25, 2010

Deferred tax liability		$	19,591	$	30,050
Long-term pension liability			28,947		36,335
Accrued Executive Supplemental Life Insurance Retirement Plan and Deferred Compensation Plan			25,446		24,659
Other long-term liabilities			23,105		23,552
Long-term liabilities of discontinued businesses			2,590		—

	Other long-term liabilities	$	99,679	$	114,596

Marketable Securities

9 Months Ended

Sep. 24, 2011

Marketable Securities

Marketable Securities

4. Marketable Securities

The amortized cost, gross unrealized gains, gross unrealized losses and fair value for marketable securities by major security type were as follows:

	September 24, 2011

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Time deposits	$	6,188	$	—	$	—		$	6,188
Auction rate securities		11,972		—		(902	)		11,070

	$	18,160	$	—	$	(902	)	$	17,258

	December 25, 2010

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Time deposits	$	9,834	$	—	$	—		$	9,834
Auction rate securities		11,974		—		(597	)		11,377

	$	21,808	$	—	$	(597	)	$	21,211

As of September 24, 2011, we held $11,070 in auction rate securities which are variable rate debt instruments, which bear interest rates that reset approximately every 35 days. The auction rate securities owned were rated AAA by a major credit rating agency and are guaranteed by the Federal Family Education Loan Program (FFELP). The underlying securities have contractual maturities which are generally greater than ten years. The auction rate securities are classified as available for sale and are recorded at fair value.

Maturities of debt securities were as follows:

	September 24, 2011				December 25, 2010

	Amortized Cost		Fair Value		Amortized Cost		Fair Value
Due less than one year	$	6,188	$	6,188	$	9,834	$	9,834
Due after one year through five years		—		—		—		—
Due after ten years		11,972		11,070		11,974		11,377

	$	18,160	$	17,258	$	21,808	$	21,211

Fair Value

9 Months Ended

Sep. 24, 2011

Fair Value

Fair Value

5. Fair Value

We hold cash equivalents, investments and certain other assets that are carried at fair value. We generally determine fair value using a market approach based on quoted prices of identical instruments when available. When market quotes of identical instruments are not readily accessible or available, we determine fair value based on quoted market prices of similar instruments. We enter into forward currency contracts to hedge the foreign currency risk associated with market fluctuations of foreign currency rates on the financial statements.

The valuation hierarchy for disclosure of the inputs used to measure fair value prioritizes the inputs into three broad levels as follows. Level 1 inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities. Level 2 inputs are quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets in markets that are not active, inputs other than quoted prices that are observable for the asset or liability, including interest rates, yield curves and credit risks, or inputs that are derived principally from or corroborated by observable market data through correlation. Level 3 inputs are unobservable inputs based on our own assumptions used to measure assets and liabilities at fair value. A financial asset or liability's classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement.

On September 14, 2010, we entered into a fair market value hedge contract with a bank. The terms of this contract were for the bank to deliver 62,637 Canadian dollars to us, and for us to deliver 46,940 Euro to our bank on the same date. The hedge was terminated on June 28, 2011, and was settled for approximately $4,008. On September 23, 2011, we entered into a forward foreign currency contract to hedge the foreign exchange impact of an intercompany loan between two subsidiaries with different functional currencies. As of September 24, 2011, the outstanding forward contract had a fair value of negative $45, which was recorded as a loss and included in other income (expense) for the period.

During the second quarter of 2011, we received life insurance proceeds of $9,500 related to a former officer. We recognized a tax exempt gain of $7,710 representing the difference between the life insurance proceeds and the cash surrender value.

During the second quarter of 2011, we reduced the fair value of the contingent consideration attributable to the acquisition of the Systems Pathology Company, LLC (SPC) by $1,206 based upon financial projections.

Assets and liabilities measured at fair value on a recurring basis are summarized below:

	Fair Value Measurements at September 24, 2011 using

	Quoted Prices in Active Markets for Identical Assets Level 1		Significant Other Observable Inputs Level 2			Significant Unobservable Inputs Level 3		Assets at Fair Value
Time deposits	$	—	$	6,188		$	—	$	6,188
Auction rate securities		—		—			11,070		11,070
Fair value of life policies		—		18,690			—		18,690
Hedge contract		—		(45	)		—		(45	)

Total assets	$	—	$	24,833		$	11,070	$	35,903

Contingent consideration		—		—			4,392		4,392

Total liabilities	$	—	$	—		$	4,392	$	4,392

	Fair Value Measurements at December 25, 2010 using

	Quoted Prices in Active Markets for Identical Assets Level 1		Significant Other Observable Inputs Level 2		Significant Unobservable Inputs Level 3		Assets at Fair Value
Time deposits	$	—	$	9,834	$	—	$	9,834
Auction rate securities		—		—		11,377		11,377
Fair value of life policies		—		25,609		—		25,609
Hedge contract		—		419		—		419

Total assets	$	—	$	35,862	$	11,377	$	47,239

Contingent consideration		—		—		5,365		5,365

Total liabilities	$	—	$	—	$	5,365	$	5,365

Descriptions of the valuation methodologies used for assets and liabilities measured at fair value are as follows:

•

Time deposits—Valued at their ending balances, as reported by the financial institutions that hold our securities, which approximates fair value. These valuations are reviewed by management.

•

Auction rate securities—Valued at fair value in part utilizing an independent valuation reviewed by management which used pricing models and discounted cash flow methodologies incorporating assumptions that a marketplace participant would use at September 24, 2011.

•

Life policies—Valued at cash surrender value.

•

Hedge contract—Valued at fair value by management; valuations were based on calculations using foreign exchange rates at the financial statement date.

•

Contingent consideration—Consists of future acquisition-related payments based on certain agreed upon revenue and technical milestones valued using the income approach. Key assumptions included a discount rate of 18% and probability adjustments ranging from 5% to 70%.

The table below presents a reconciliation of all assets and liabilities measured at fair value on a recurring basis using significant unobservable inputs (Level 3) during the nine months ended September 24, 2011 and September 25, 2010.

		Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

		Nine months ended
Auction rate securities		September 24, 2011			September 25, 2010
Beginning balance		$	11,377		$	16,212
Transfers in and/or out of Level 3			—			—
Total gains or losses (realized/unrealized):
	Included in earnings (other expenses)		(1	)		15
	Included in other comprehensive income		(306	)		574
Purchases, issuances and settlements			—			(5,500	)

Ending balance		$	11,070		$	11,301

		Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

		Nine months ended
Contingent consideration		September 24, 2011			September 25, 2010
Beginning balance		$	5,365		$	9,300
Transfers in and/or out of Level 3			—			—
Total gains or losses (realized/unrealized):
	Included in (earnings) other expenses		(973	)		(2,530	)
	Included in other comprehensive income		—			—
Purchases, issuances and settlements			—			—

Ending balance		$	4,392		$	6,770

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 44A, 44B
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15C, 15D
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15A
-Subparagraph a-d
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15B
-Subparagraph a, b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 3, 10, 14, 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 157
-Paragraph 32, 33, 34
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 159
-Paragraph 17-22, 27, 28
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6925170&loc=d3e19207-110258

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 21
-URI http://asc.fasb.org/extlink&oid=6947722&loc=d3e13537-108611

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 28
-URI http://asc.fasb.org/extlink&oid=6957238&loc=d3e14064-108612

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=6947722&loc=d3e13433-108611

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 30
-URI http://asc.fasb.org/extlink&oid=6957238&loc=d3e14172-108612

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 16
-URI http://asc.fasb.org/extlink&oid=6947722&loc=d3e13504-108611

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6925170&loc=d3e19296-110258

+ Details

Goodwill and Other Intangible Assets

9 Months Ended

Sep. 24, 2011

Goodwill and Other Intangible Assets

Goodwill and Other Intangible Assets

6. Goodwill and Other Intangible Assets

The following table displays goodwill and other intangible assets not subject to amortization and other intangible assets that continue to be subject to amortization:

		September 24, 2011							December 25, 2010

		Gross Carrying Amount		Accumulated Amortization & Impairment loss			Net Amount		Gross Carrying Amount		Accumulated Amortization & Impairment loss			Net Amount
Goodwill		$	1,216,569	$	(1,016,770	)	$	199,799	$	1,216,196	$	(1,017,758	)	$	198,438

Other intangible assets not subject to amortization:
	Research models	$	3,438	$	—		$	3,438	$	3,438	$	—		$	3,438
	PCS in process R&D		6,800		—			6,800		6,800		—			6,800
Other intangible assets subject to amortization:
	Backlog		2,942		(2,240	)		702		2,839		(2,109	)		730
	Customer relationships		292,263		(195,262	)		97,001		301,175		(192,345	)		108,830
	Customer contracts		15,259		(15,259	)		—		15,259		(15,259	)		—
	Trademarks and trade names		4,649		(4,649	)		—		5,041		(4,614	)		427
	Standard operating procedures		657		(657	)		—		657		(657	)		—
	Other identifiable intangible assets		4,300		(4,300	)		—		5,428		(4,417	)		1,011

Total other intangible assets		$	328,308	$	(222,367	)	$	105,941	$	340,637	$	(219,401	)	$	121,236

The changes in the gross carrying amount and accumulated amortization of goodwill are as follows:

					Adjustments to Goodwill

		Balance at December 25, 2010			Acquisitions		Foreign Exchange/ Other			Balance at September 24, 2011
Research Models and Services
	Gross carrying amount	$	57,876		$	—	$	(996	)	$	56,880
	Accumulated amortization		(4,768	)		—		1,000			(3,768	)
Preclinical Services
	Gross carrying amount		1,158,320			—		1,369			1,159,689
	Accumulated impairment loss		(1,005,000	)		—		—			(1,005,000	)
	Accumulated amortization		(7,990	)		—		(13	)		(8,003	)
Total
	Gross carrying amount	$	1,216,196		$	—	$	373		$	1,216,569
	Accumulated impairment loss		(1,005,000	)		—		—			(1,005,000	)
	Accumulated amortization		(12,758	)		—		988			(11,770	)

- Definition

The entire disclosure for the aggregate amount of goodwill and a description of intangible assets, which may include (a) for amortizable intangible assets (also referred to as finite-lived intangible assets), the carrying amount, the amount of any significant residual value, and the weighted-average amortization period, (b) for intangible assets not subject to amortization (also referred to as indefinite-lived intangible assets), the carrying amount, and (c) the amount of research and development assets acquired and written off in the period, including the line item in the income statement in which the amounts written off are aggregated, if not readily apparent from the income statement. Also discloses (a) for amortizable intangibles assets in total and by major class, the gross carrying amount and accumulated amortization, the total amortization expense for the period, and the estimated aggregate amortization expense for each of the five succeeding fiscal years, (b) for intangible assets not subject to amortization the carrying amount in total and by major class, and (c) for goodwill, in total and for each reportable segment, the changes in the carrying amount of goodwill during the period (including the aggregate amount of goodwill acquired, the aggregate amount of impairment losses recognized, and the amount of goodwill included in the gain (loss) on disposal of a reporting unit). If any part of goodwill has not been allocated to a reportable segment, discloses the unallocated amount and the reasons for not allocating. For each impairment loss recognized related to an intangible asset (excluding goodwill), discloses: (a) a description of the impaired intangible asset and the facts and circumstances leading to the impairment, (b) the amount of the impairment loss and the method for determining fair value, (c) the caption in the income statement or the statement of activities in which the impairment loss is aggregated, and (d) the segment in which the impaired intangible asset is reported. For each goodwill impairment loss recognized, discloses: (a) a description of the facts and circumstances leading to the impairment, (b) the amount of the impairment loss and the method of determining the fair value of the associated reporting unit, and (c) if a recognized impairment loss is an estimate not finalized and the reasons why the estimate is not final. May also disclose the nature and amount of any significant adjustments made to a previous estimate of an impairment loss.

+ References + Details

Long-Term Debt

9 Months Ended

Sep. 24, 2011

Long-Term Debt

Long-Term Debt

7. Long-Term Debt

Long-Term Debt

Long-term debt consists of the following:

		September 24, 2011			December 25, 2010

2.25% Senior convertible debentures:
	Principal	$	349,995		$	349,995
	Unamortized debt discount		(25,317	)		(35,583	)

Net carrying amount of senior convertible debentures			324,678			314,412
Term loan facilities			393,465			386,213
Revolving credit facility			22,000			—
Other debt, represents secured and unsecured promissory notes, interest rates ranging from 0% to .5% and 0% to 0.5% at September 24, 2011 and December 25, 2010, respectively, maturing between 2011 and 2012			123			127

Total debt			740,266			700,752
Capital leases			55			100

Total debt and capital leases			740,321			700,852
Less: current portion of long-term debt and capital leases			(19,838	)		(30,582	)

Long-term debt and capital leases		$	720,483		$	670,270

On December 25, 2010, we had a $750,000 credit agreement, which had a maturity date of August 26, 2015 and provided for a $230,000 term loan, a €133,762 Euro term loan and a $350,000 revolving credit facility. On February 24, 2011 we amended the credit agreement, primarily to provide for an incremental $150,000 term loan and to modify the leverage ratio used in calculating the interest rate applicable to amounts outstanding. On September 23, 2011, we amended and restated the credit agreement primarily to reduce the interest rate margin applicable to the term loans and the revolving loans based on our leverage ratio and extend the maturity date by one year (i.e., to September 2016). The current credit agreement provides for a $299,750 term loan, a €69,414 Euro term loan and a $350,000 revolving credit facility. Under specified circumstances, we have the ability to increase the term loans and/or revolving line of credit by up to $250,000 in the aggregate. Our obligations under the credit agreement are guaranteed by our material domestic subsidiaries and are secured by substantially all of our assets, including a pledge of 100% of the capital stock of our domestic subsidiaries (other than the capital stock of any domestic subsidiary that is treated as a disregarded entity for U.S. federal income tax purposes) and 65% of the capital stock of certain first-tier foreign subsidiaries and domestic disregarded entities, and mortgages on owned real property in the U.S. having a book value in excess of $10,000. The term loans mature in 20 quarterly installments with the last installment due September 23, 2016. The $350,000 revolving facility also matures on September 23, 2016 and requires no scheduled payment before that date. The credit agreement contains certain customary representations and warranties, affirmative covenants and events of default.

The interest rates applicable to term loans and revolving loans under the credit agreement are, at our option, equal to either the base rate (which is the higher of (1) the prime rate, (2) the federal funds rate plus 0.50% or (3) the one-month adjusted LIBOR rate plus 1%) plus an applicable interest rate margin based upon the leverage ratio or the adjusted LIBOR rate plus an interest rate margin based upon our leverage ratio.

Based on our current leverage ratio, the margin range for base rate loans is 0.0% to 0.75% and the margin range for LIBOR based loans is 1.00% to 1.75%. As of September 24, 2011, the interest rate margin for base rate loans was 0.75% and for adjusted LIBOR loans was 1.75%. The book value of our term and revolving loans approximates fair value.

We pledged the stock of certain subsidiaries as well as certain U.S. assets for our credit agreements. In addition, the credit agreement includes certain customary representations and warranties, events of default, notices of material adverse changes to our business and negative and affirmative covenants. These covenants include (1) the ratio of consolidated earnings before interest, taxes, depreciation and amortization less capital expenditures to consolidated cash interest expense, which for any period of four consecutive fiscal quarters must be no less than 3.5 to 1.0, as well as (2) the ratio of consolidated indebtedness to consolidated earnings before interest, taxes, depreciation and amortization for any period of four of the previous consecutive fiscal quarters of no more than 4 to 1. In the second and third quarter of 2012, this ratio will step down to 3.5 to 1, and thereafter will step down to 3.25 to 1. As of September 24, 2011, we were compliant with all financial covenants specified in the credit agreement. We had $4,475 outstanding under letters of credit as of September 24, 2011.

Our $350,000 of 2.25% Convertible Senior Notes (the 2013 Notes) due in June 2013 with interest payable semi-annually are convertible into cash for the principal amount and shares of our common stock for the conversion premium (or, at our election, cash in lieu of some or all of such common stock), if any, based on an initial conversion rate, subject to adjustment, of 20.4337 shares of our common stock per $1,000 principal amount of notes (which represents an initial conversion price of $48.94 per share), only in the following circumstances and to the following extent: (1) during any fiscal quarter beginning after July 1, 2006 (and only during such fiscal quarter), if the last reported sale price of our common stock for at least 20 trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding fiscal quarter is more than 130% of the conversion price on the last day of such preceding fiscal quarter; (2) during the five business-day period after any five consecutive trading-day period, or the measurement period, in which the trading price per note for each day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such day; (3) upon the occurrence of specified corporate transactions, as described in the indenture for the 2013 Notes; and (4) at the option of the holder at any time beginning on the date that is two months prior to the stated maturity date and ending on the close of business on the second trading-day immediately preceding the maturity date. Upon conversion, we will pay cash and shares of our common stock (or, at our election, cash in lieu of some or all of such common stock), if any. If we undergo a fundamental change as described in the indenture for the 2013 Notes, holders will have the option to require us to purchase all or any portion of their notes for cash at a price equal to 100% of the principal amount of the notes to be purchased plus any accrued and unpaid interest, including any additional interest to, but excluding, the purchase date.

At September 24, 2011, the fair value of our outstanding 2013 Notes was approximately $343,940 based on their quoted market value and no conversion triggers were met.

As of September 24, 2011, $25,317of debt discount remained and will be amortized over 7 quarters. As of September 24, 2011 and December 25, 2010, the equity component of our convertible debt was $88,492. Interest expense related to our convertible debt of $3,514 and $3,349 for the quarters ended September 24, 2011 and September 25, 2010, respectively, and for the nine months ended September 24, 2011 and September 25, 2010 of $10,266 and $9,664, respectively, yielded an effective interest rate of 6.93% on the liability component. In addition, $1,969 and $5,906 of contractual interest expense was recognized on our convertible debt during the three and nine months ended September 24, 2011 and $1,969 and $5,906 of contractual interest expense was recognized on our convertible debt during the three and nine months ended September 25, 2010.

Principal maturities of existing debt which excludes unamortized debt discount for the periods set forth in the table below are as follows:

Twelve months ending

September 2012		$	19,796
September 2013			379,505
September 2014			54,102
September 2015			73,775
September 2016			238,405

	Total	$	765,583

We have capital leases for equipment. These leases are capitalized using interest rates considered appropriate at the inception of each lease. Capital lease obligations amounted to $55 and $100 at September 24, 2011 and December 25, 2010, respectively.

Equity

9 Months Ended

Sep. 24, 2011

Equity

Equity

8. Equity

Earnings per Share

Basic earnings per share for the three and nine months ended September 24, 2011 and September 25, 2010 were computed by dividing earnings available to common shareowners for these periods by the weighted average number of common shares outstanding in the respective periods adjusted for contingently issuable shares. The weighted average number of common shares outstanding for the three and nine months ended September 24, 2011 and September 25, 2010 has been adjusted to include common stock equivalents for the purpose of calculating diluted earnings per share for these periods.

Options to purchase 4,253,703 and 5,112,792 shares were outstanding in each of the three respective months ended September 24, 2011 and September 25, 2010, but were not included in computing diluted earnings per share because their inclusion would have been anti-dilutive. Options to purchase 4,245,953 and 4,363,966 shares were outstanding in each of the respective nine months ended September 24, 2011 and September 25, 2010, but were not included in computing diluted earnings per share because their inclusion would have been anti-dilutive.

Basic weighted average shares outstanding for the three and nine months ended September 24, 2011 and September 25, 2010 excluded the weighted average share impact of 705,662 and 873,126, respectively, of non-vested fixed restricted stock awards.

The following table illustrates the reconciliation of the numerator and denominator in the computations of the basic and diluted earnings per share:

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Numerator:
Income (loss) from continuing operations for purposes of calculating earnings per share		$	18,816		$	(23,955	)	$	88,146		$	9,358
Loss from discontinued businesses		$	(18	)	$	(986	)	$	(5,695	)	$	(2,463	)
Denominator:
Weighted average shares outstanding—Basic			50,084,850			62,597,055			51,671,559			64,344,970
Effect of dilutive securities:
	2.25% senior convertible debentures		—			—			—			—
	Stock options and contingently issued restricted stock		448,897			—			566,868			549,855
	Warrants		—			—			—			—

Weighted average shares outstanding—Diluted			50,533,747			62,597,055			52,238,427			64,894,825

Basic earnings per share from continuing operations		$	0.38		$	(0.38	)	$	1.71		$	0.15
Basic loss per share from discontinued operations			—		$	(0.02	)	$	(0.11	)	$	(0.04	)
Diluted earnings per share from continuing operations		$	0.37		$	(0.38	)	$	1.69		$	0.14
Diluted loss per share from discontinued operations			—		$	(0.02	)	$	(0.11	)	$	(0.04	)

Treasury Shares and Accelerated Stock Repurchase Program (ASR)

On October 20, 2010, our Board of Directors increased our stock repurchase authorization to $750,000. In order to enable us to facilitate, on a more timely and cost efficient basis, the repurchase of a substantial number of our shares pursuant to that stock repurchase authorization we entered into agreements with a third party investment bank to implement an accelerated stock repurchase (ASR) program. We entered into an ASR on February 24, 2011 to repurchase $150,000 of common stock. Under the ASR, we paid $150,000 from cash on hand and available liquidity, including funds borrowed by us under our credit facility. The ASR program was recorded as two transactions allocated between the initial purchase of treasury stock and a forward contract indexed to our common stock. Upon signing the February 24, 2011 ASR we received the initial delivery of 3,759,398 shares, which was recorded at $135,860 based on the market value at the date of the transaction and recorded $14,140 as a forward contract indexed to our common stock. On May16, 2011, we received the final 6,505 shares under the ASR, which were recorded at $257.

We had entered into an ASR on August 26, 2010 to repurchase $300,000 of common stock. On August 27, 2010, under the ASR we paid $300,000 from cash on hand and available liquidity, including funds borrowed by us under our credit facility. During 2010, pursuant to the ASR we received 8,000,000 shares. On February 11, 2011, we received the final 871,829 shares under the ASR, which were recorded at $32,509.

Additionally, during the nine months ended September 24, 2011, we repurchased 2,946,468 shares for $105,852 on the open market in reliance on Rules 10b-18 and 10b5-1, of the Securities Exchange Act of 1934, as amended.

Additionally, our 2000 Incentive Plan and 2007 Incentive Plan permit the netting of common stock upon vesting of restricted stock awards in order to satisfy individual tax withholding requirements. During the three months ended September 24, 2011 and September 25, 2010, respectively, we acquired 1,056 shares for $39 and 18,674 shares for $568, as a result of such withholdings. During the nine months ended September 24, 2011 and September 25, 2010, we acquired 79,663 shares for $2,942 and 97,300 shares for $3,533, respectively.

The total number of shares repurchased during the nine months ended September 24, 2011 and September 25, 2010 was as follows:

	Nine Months Ended

	September 24, 2011		September 25, 2010
Number of shares of common stock repurchased		7,663,863		8,607,157
Total cost of repurchase	$	277,420	$	254,998

The timing and amount of any future repurchases will depend on market conditions and corporate considerations.

Warrants

Separately and concurrently with the pricing of the 2013 Notes, we issued warrants for approximately 7.2 million shares of our common stock. The warrants give the holders the right to receive, for no additional consideration, cash or shares (at our option) with a value equal to the appreciation in the price of our shares above $59.925, and expire between September 13, 2013 and January 22, 2014 over 90 equal increments. The total proceeds from the issuance of the warrants were $65,423.

Changes in Equity

A summary of the changes in equity for the nine months ended September 24, 2011 and September 25, 2010 is provided below:

		Nine Months Ended

		September 24, 2011								September 25, 2010
		Shareowners' Equity			Noncontrolling Interest		Total Equity			Shareowners' Equity			Noncontrolling Interest			Total Equity
Equity, beginning of the period		$	687,423		$	1,304	$	688,727		$	1,375,243		$	(1,419	)	$	1,373,824
Components of comprehensive income, net of tax:
	Net income		82,451			298		82,749			6,895			(1,034	)		5,861
	Foreign currency translation adjustment		(7,834	)		56		(7,778	)		(9,818	)		(81	)		(9,899	)
	Amortization of pension, net gain/loss and prior service cost		483			—		483			260			—			260
	Unrealized loss on marketable securities		(305	)		—		(305	)		775			—			775

Total comprehensive income			74,795			354		75,149			(1,888	)		(1,115	)		(3,003	)
	Dividends paid noncontrolling interest		—			—		—			—			(270	)		(270	)
	Tax detriment associated with stock issued under employee compensation plans		(1,110	)		—		(1,110	)		(538	)		—			(538	)
	Issuance of stock under employee compensation plans		20,478			—		20,478			3,133			—			3,133
	Acquisition of treasury shares		(244,654	)		—		(244,654	)		(254,998	)		—			(254,998	)
	Acquisition of ASR equity instrument		(14,140	)		—		(14,140	)		(101,423	)		—			(101,423	)
	Stock-based compensation		16,919			—		16,919			21,443			—			21,443

Equity, end of the period		$	539,711		$	1,658	$	541,369		$	1,040,972		$	(2,804	)	$	1,038,168

- Definition

The entire disclosure for shareholders' equity, comprised of portions attributable to the parent entity and noncontrolling interest, if any, including other comprehensive income (as applicable). Including, but not limited to: (1) balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings; (2) accumulated balance for each classification of other comprehensive income and total amount of comprehensive income; (3) amount and nature of changes in separate accounts, including the number of shares authorized and outstanding, number of shares issued upon exercise and conversion, and for other comprehensive income, the adjustments for reclassifications to net income; (4) rights and privileges of each class of stock authorized; (5) basis of treasury stock, if other than cost, and amounts paid and accounting treatment for treasury stock purchased significantly in excess of market; (6) dividends paid or payable per share and in the aggregate for each class of stock for each period presented; (7) dividend restrictions and accumulated preferred dividends in arrears (in aggregate and per share amount); (8) retained earnings appropriations or restrictions, such as dividend restrictions; (9) impact of change in accounting principle, initial adoption of new accounting principle and correction of an error in previously issued financial statements; (10) shares held in trust for Employee Stock Ownership Plan (ESOP); (11) deferred compensation related to issuance of capital stock; (12) note received for issuance of stock; (13) unamortized discount on shares; (14) description, terms, and number of warrants or rights outstanding; (15) shares under subscription and subscription receivables, effective date of new retained earnings after quasi-reorganization and deficit eliminated by quasi-reorganization and, for a period of at least ten years after the effective date, the point in time from which the new retained dates; and (16) retroactive effective of subsequent change in capital structure.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Principles Board Opinion (APB)
-Number 12
-Paragraph 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 04
-Article 3

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Article 4
-Section 08
-Paragraph d

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 43
-Chapter 1
-Section B
-Paragraph 7, 11A
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 129
-Paragraph 2, 3, 4, 5, 6, 7, 8
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 08
-Article 4

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 5
-Paragraph 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 29, 30, 31
-Article 5

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 4
-Section E

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 4
-Section C

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-URI http://asc.fasb.org/extlink&oid=6959260&loc=d3e187085-122770

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21484-112644

Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 11
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21564-112644

Reference 16: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21488-112644

Reference 17: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(d),(e))
-URI http://asc.fasb.org/extlink&oid=6881521&loc=d3e23780-122690

Reference 18: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21506-112644

Reference 19: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 30
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6405834&loc=d3e23285-112656

Reference 20: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 310
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB TOPIC 4.E)
-URI http://asc.fasb.org/extlink&oid=6228006&loc=d3e74512-122707

Reference 21: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Preferred Stock
-URI http://asc.fasb.org/extlink&oid=6521494

Reference 22: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.29-31)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 23: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 4
-Subparagraph (SAB TOPIC 4.C)
-URI http://asc.fasb.org/extlink&oid=6959260&loc=d3e187143-122770

+ Details

Income Taxes

9 Months Ended

Sep. 24, 2011

Income Taxes

Income Taxes

9. Income Taxes

The following table provides a reconciliation of the provision for income taxes on the condensed consolidated statements of operations:

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Income before income taxes	$	24,541		$	(7,578	)	$	100,008		$	38,901
Effective tax rate		22.9	%		(220.0	)%		11.6	%		78.6	%
Provision for income taxes	$	5,630		$	16,670		$	11,564		$	30,577

Our overall effective tax rate was 22.9% in the third quarter of 2011 and (220.0)% in the third quarter of 2010. The change was primarily attributable to the effective tax rate in the third quarter of 2010 reflecting the cost of the $30,000 fee associated with termination of the WuXi acquisition, which was not benefitted for tax purposes, and the cost of changing the Company's indefinite reinvestment assertion with respect to approximately $205,400 of non-U.S. earnings. Tax expense for the third quarter of 2011 reflects the benefits of $1,366 due to the settlement of the German tax audit and $486 due to remeasurement of our deferred taxes for the decline in the statutory tax rate in the United Kingdom. These benefits are partially offset by a detriment reflected in the third quarter of 2011 of $747 for a provision to return adjustment in the United States primarily due to the cost of 2010 repatriation.

The effective tax rate for the nine months ended September 24, 2011 reflects an $11,111 tax benefit recorded in the first quarter of 2011 associated with a tax loss incurred on the disposition of the Company's Phase I clinical business and the receipt of a $7,710 tax exempt gain on the settlement of a life insurance policy received in the second quarter of 2011. The effective tax rate for the nine months ended September 25, 2010 reflects the unbenefitted WuXi termination fee and the cost of changing the Company's indefinite reinvestment assertion with respect to approximately $27,100 and $205,400 of its non-U.S. earnings in the second and third quarters of 2010, respectively.

In accordance with Canadian Federal tax law, we claim Scientific Research and Experimental Development credits (SR&ED credits) on qualified research and development costs incurred by our preclinical service facility in Canada in the performance of projects for non-Canadian customers. Additionally, in accordance with the tax law of the United Kingdom, we claim enhanced deductions related to qualified research and development costs incurred by our preclinical service facility in Edinburgh, Scotland in the performance of certain customer contracts.

During the fourth quarter of 2010, we took actions to divest the Company's Phase I clinical business. We recorded in discontinued operations a deferred tax asset associated with the excess of the tax outside basis over the basis for financial reporting purposes of the Phase I clinical business. As of the fourth quarter, we determined that it was not more-likely-than-not that the Company would realize this deferred tax asset and we recorded a valuation allowance against it as part of discontinued operations. During the first quarter of 2011, we determined that the tax loss would more-likely-than-not be benefitted as a worthless stock deduction. As such, we eliminated the valuation allowance recorded to offset the tax loss on the Phase I clinical business, and recognized the benefit in continuing operations.

During the third quarter of 2011, our unrecognized tax benefits recorded decreased by $7,780 to $27,517 primarily due to the settlement of the German audit, and foreign exchange movement partially offset by increases due to ongoing evaluation of uncertain tax positions in the current period. The amount of unrecognized tax benefits that would impact the effective tax rate favorably if recognized decreased by $7,731 to $22,182 and the amount of accrued interest on unrecognized tax benefits decreased by $1,099 to $1,409 primarily due to the German audit settlement. This decrease was partially offset by increases due to ongoing evaluation of uncertain tax positions in the current and prior periods as well as foreign exchange movement in the third quarter of 2011.

We conduct business in a number of tax jurisdictions. As a result, we are subject to tax audits in jurisdictions including, but not limited to, the United States, the United Kingdom, Japan, France, Germany and Canada. With few exceptions, we are no longer subject to U.S. and international income tax examinations for years before 2003.

During the third quarter of 2011 we settled an audit with the German Tax Office. Resolution of this controversy, which related to the deductibility of interest, resulted in the recognition of a tax benefit of $1,366 during the quarter.

Additionally, we are challenging the reassessments received by the Canada Revenue Agency (CRA) with respect to the SR&ED credits claimed in 2003 and 2004 by our Canadian preclinical services subsidiary in the Tax Court of Canada (TCC). In the fourth quarter of 2009 and the first quarter of 2010, we filed Notices of Appeal with the TCC and received the Crown's response in the second quarter of 2010. In a related development, during the first quarter of 2010 we received Notices of Reassessment from the Minister of Revenue of Quebec (MRQ) provincial tax authorities with respect to the Quebec Research and Development tax credit. We filed Notices of Objection with the MRQ in the second quarter of 2010. We disagree with the positions taken by the CRA and MRQ with regard to the credits claimed. We believe that it is reasonably possible that we will conclude the controversies with the TCC and MRQ within the next twelve months. However, pending resolution of the reassessments with the TCC, it is possible that the CRA and MRQ will propose similar adjustments for later years. We do not believe that resolution of these controversies will have a material impact on our financial position, cash flows or results of operations.

We believe we have appropriately provided for all unrecognized tax benefits.

In accordance with our policy, the undistributed earnings of our non-U.S. subsidiaries remain indefinitely reinvested as of the end of the third quarter of 2011 as they are required to fund needs outside the U.S. and cannot be repatriated in a manner that is substantially tax-free. During the third quarter of 2011, we restructured our international operations in a tax-free manner to allow us more flexibility in accessing our offshore cash to fund needs outside the U.S.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 08
-Paragraph h
-Article 4

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 109
-Paragraph 136, 172
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 109
-Paragraph 43, 44, 45, 46, 47, 48, 49
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32718-109319

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(h))
-URI http://asc.fasb.org/extlink&oid=6881521&loc=d3e23780-122690

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32559-109319

+ Details

Employee Benefits

9 Months Ended

Sep. 24, 2011

Employee Benefits

Employee Benefits

10. Employee Benefits

The following table provides the components of net periodic benefit cost for our defined benefit plans:

Pension Benefits

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Service cost		$	758		$	793		$	2,279		$	1,906
Interest cost			3,016			2,903			9,056			8,398
Expected return on plan assets			(3,407	)		(3,165	)		(10,213	)		(9,295	)
Amortization of prior service cost			(155	)		(148	)		(466	)		(447	)
Amortization of net loss (gain)			239			178			693			534

	Net periodic benefit cost	$	451		$	561		$	1,349		$	1,096

Company contributions		$	1,100		$	1,913		$	7,119		$	5,536

Supplemental Retirement Benefits

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Service cost		$	159	$	149	$	477	$	447
Interest cost			300		335		901		1,005
Amortization of prior service cost			125		124		374		374
Amortization of net loss (gain)			53		38		158		114

	Net periodic benefit cost	$	637	$	646	$	1,910	$	1,940

For the fiscal year ended 2011, we expect to contribute a total of $10,666 to our plans.

- Definition

The entire disclosure for pension and other postretirement benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5
-Subparagraph a
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5
-Subparagraph b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5
-Subparagraph h
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5
-Subparagraph q
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 8
-Subparagraph m
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 106
-Paragraph 518
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 87
-Paragraph 264
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Emerging Issues Task Force (EITF)
-Number 03-2
-Paragraph 8
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Principles Board Opinion (APB)
-Number 30
-Paragraph 26
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS106-2
-Paragraph 20, 21, 22
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 158
-Paragraph 7, 21, 22
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5, 6, 7, 8
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Implementation Guide (Q and A)
-Number FAS88
-Paragraph 63
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 715
-URI http://asc.fasb.org/topic&trid=2235017

+ Details

Stock-Based Compensation

9 Months Ended

Sep. 24, 2011

Stock-Based Compensation

Stock-Based Compensation

11. Stock-Based Compensation

The estimated fair value of our stock-based awards, less expected forfeitures, is amortized over the awards' vesting period on a straight-line basis. The following table presents stock-based compensation included in our consolidated statements of operations:

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Stock-based compensation expense in:
	Cost of sales	$	1,626		$	1,838		$	5,003		$	6,088
	Selling and administration		3,945			4,933			11,916			15,355

	Income before income taxes		5,571			6,771			16,919			21,443
	Provision for income taxes		(1,991	)		(2,441	)		(6,050	)		(7,760	)

Net income attributable to common shareowners		$	3,580		$	4,330		$	10,869		$	13,683

We did not capitalize any stock-based compensation related costs for the quarters or the nine months ended September 24, 2011 and September 25, 2010.

The fair value of stock-based awards granted during the first nine months of 2011 and 2010 was estimated on the grant date using the Black-Scholes option-pricing model with the following weighted-average assumptions:

	Options Granted In:

	2011			2010
Expected life (in years)		4.2			4.5
Expected volatility		33.4	%		34.0	%
Risk-free interest rate		2.22	%		2.35	%
Expected dividend yield		0.0	%		0.0	%
Weighted-average grant date fair value	$	11.35		$	11.96

Stock Options

The following table summarizes the stock option activity in the equity incentive plans for the nine months ended September 24, 2011:

			Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value

Options outstanding as of December 25, 2010	6,594,313		$	37.87
Options granted	950,190		$	37.38
Options exercised	(719,489	)	$	28.46
Options canceled	(669,454	)	$	43.77

Options outstanding as of September 24, 2011	6,155,560		$	38.25	3.96 years	$	5,769

Options exercisable as of September 24, 2011	3,610,841		$	40.58	2.94 years	$	2,424

As of September 24, 2011, the unrecognized compensation cost related to unvested stock options expected to vest was $20,066. This unrecognized compensation will be recognized over an estimated weighted-average amortization period of 30 months.

The total intrinsic value of options exercised during the three and nine months ended September 24, 2011 was $1,204 and $7,914, respectively. The total intrinsic value of options exercised during the three and nine months ended September 25, 2010 was $128 and $1,269, respectively. Intrinsic value is defined as the difference between the market price on the date of exercise and the grant date price. The total amount of cash received from the exercise of options during the nine months ended September 24, 2011 and September 25, 2010 was $20,574 and $3,118, respectively. The actual tax benefit realized for the tax deductions from option exercises totaled $2,881 and $370 for the nine months ending September 24, 2011 and September 25, 2010, respectively. In the first nine months of 2011, $1,110 was recorded in capital in excess of par value for the excess of deferred tax assets over the actual tax benefits at option exercise. We settle employee stock option exercises with newly issued common shares.

Restricted Stock

Stock compensation expense associated with restricted common stock is charged for the market value on the date of grant, less estimated forfeitures, and is amortized over the awards' vesting period on a straight-line basis.

The following table summarizes the restricted stock activity from December 25, 2010 through September 24, 2011:

				Weighted-Average Grant Date Fair Value

Outstanding December 25, 2010		777,740		$	35.97
	Granted	284,480		$	37.30
	Vested	(295,457	)	$	37.64
	Canceled	(61,101	)	$	37.84

Outstanding September 24, 2011		705,662		$	35.64

As of September 24, 2011, the unrecognized compensation cost related to shares of unvested restricted stock expected to vest was $18,955. This unrecognized compensation will be recognized over an estimated weighted-average amortization period of 30 months. The total fair value of restricted stock grants that vested during the three and nine months ended September 24, 2011 was $122 and $10,985, respectively. The total fair value of restricted stock grants that vested during the three and nine months ended September 25, 2010 was $2,516 and $12,510, respectively.

Performance Based Stock Award Program

During the three months ending September 24, 2011 and September 25, 2010, compensation expense of $54 and $105, respectively, was recorded associated with performance based stock awards. During the nine months ended September 24, 2011 and September 25, 2010, compensation expense of $162 and $315, respectively, was recorded associated with these awards.

- Definition

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 123R
-Paragraph 64, 65, A240
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Statement of Position (SOP)
-Number 93-6
-Paragraph 53
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 14

Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 505
-SubTopic 50
-Section 50
-Paragraph 1
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+ Details

Commitments and Contingencies

9 Months Ended

Sep. 24, 2011

Commitments and Contingencies

Commitments and Contingencies

12. Commitments and Contingencies

Various lawsuits, claims and proceedings of a nature considered normal to our business are pending against us. In the opinion of management, the outcome of such proceedings and litigation currently pending will not materially affect our consolidated financial statements.

- Definition

The entire disclosure for commitments and contingencies.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Interpretation (FIN)
-Number 14
-Paragraph 3
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

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-Paragraph 1
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+ Details

Business Segment Information

9 Months Ended

Sep. 24, 2011

Business Segment Information

Business Segment Information

13. Business Segment Information

We report two segments, called Research Models and Services (RMS) and Preclinical Services (PCS). Operating segments are components of an enterprise for which separate financial information is available and is regularly evaluated by the chief operating decision maker in deciding how to allocate resources and in assessing performance.

Our RMS segment includes sales of research models, genetically engineered models and services (GEMS), consulting and staffing services (CSS), research animal diagnostics, discovery services, in vitro and avian vaccine services. Our PCS segment includes services required to take a drug through the development process including toxicology, pathology services, bioanalysis, pharmacokinetics and drug metabolism, discovery support and biopharmaceutical services.

The following table presents sales and other financial information by business segment. Net sales represent sales originating in entities primarily engaged in either provision of RMS or PCS.

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Research Models and Services
	Net sales	$	171,471	$	159,259	$	523,005	$	498,604
	Gross margin		70,514		64,383		222,660		210,008
	Operating income		48,534		42,817		155,967		140,059
	Depreciation and amortization		9,327		9,422		27,914		27,954
	Capital expenditures		5,789		4,622		14,202		15,827
Preclinical Services
	Net sales	$	106,108	$	111,626	$	328,680	$	353,160
	Gross margin		22,202		26,117		79,014		81,447
	Operating income		3,663		5,178		20,844		12,116
	Depreciation and amortization		11,840		14,063		36,334		42,036
	Capital expenditures		2,433		4,505		7,470		11,025

A reconciliation of segment operating income to consolidated operating income is as follows:

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Total segment operating income	$	52,197		$	47,995		$	176,811		$	152,175
Unallocated corporate overhead		(15,103	)		(11,527	)		(44,152	)		(55,528	)
Termination fee		—			(30,000	)		—			(30,000	)

Consolidated operating income	$	37,094		$	6,468		$	132,659		$	66,647

Net sales for each significant service area are as follows:

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Research models		$	86,386	$	84,234	$	269,976	$	267,690
Research model services			54,539		50,575		161,936		153,536
Other products			30,546		24,450		91,093		77,378

	Total research models		171,471		159,259		523,005		498,604
	Total preclinical services		106,108		111,626		328,680		353,160

Total sales		$	277,579	$	270,885	$	851,685	$	851,764

A summary of unallocated corporate overhead consists of the following:

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Stock-based compensation expense	$	2,825		$	3,249		$	8,339		$	9,864
U.S. retirement plans		501			1,162			2,613			2,819
Audit, tax and related expenses		855			659			2,115			1,858
Salary and bonus		3,187			4,144			12,522			13,443
Global IT		3,089			3,373			9,623			9,950
Employee health and fringe cost		(2,307	)		(1,776	)		7			(800	)
Consulting and professional services		2,628			1,315			6,160			6,197
Depreciation		1,569			1,558			4,743			4,199
Transaction (acquisition/disposition) costs		251			(810	)		565			6,587
Life insurance death benefit gain		—			—			(7,710	)		—
Other general unallocated corporate expenses		2,505			(1,347	)		5,175			1,411

	$	15,103		$	11,527		$	44,152		$	55,528

Other general unallocated corporate expenses consist of various departmental costs including those associated with departments such as senior executives, corporate accounting, legal, tax, human resources, treasury and investor relations.

- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 131
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef
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+ Details

Discontinued Operations

9 Months Ended

Sep. 24, 2011

Discontinued Operations

Discontinued Operations

14. Discontinued Operations

On March 28, 2011, we disposed of our Phase I clinical business for a nominal amount. As part of the disposal we remained the guarantor of the monthly lease payments for the Phase I facility lease. We recognized, during the second quarter of 2011, the value of the guarantee net of the buyer's related indemnity as a liability of $2,994, which will be amortized ratably over the remaining term of the lease. The facility lease runs through January 2021 with remaining payments totaling $15,060. For the three and nine months ended September 24, 2011, the discontinued businesses recorded pretax income (losses) from operations of $24 and $(8,129), respectively.

The consolidated financial statements have been reclassified to segregate, as discontinued operations, the assets and liabilities, operating results and cash flows, of the businesses being discontinued for all periods presented. Operating results from discontinued operations are as follows:

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Net sales	$	—		$	5,196		$	2,122		$	13,766
Income (loss) from operations of discontinued businesses, before income taxes		24			(1,354	)		(8,129	)		(3,727	)
Provision (benefit) for income taxes		42			(368	)		(2,434	)		(1,264	)

Loss from operations of discontinued businesses, net of taxes	$	(18	)	$	(986	)	$	(5,695	)	$	(2,463	)

Assets and liabilities of discontinued operations at September 24, 2011 and December 25, 2010 consisted of the following:

		September 24, 2011		December 25, 2010

Current assets		$	—	$	3,862
Non-current assets			1,121		822

	Total assets	$	1,121	$	4,684

Current liabilities		$	1,129	$	3,284
Non-current liabilities			2,590		—

	Total liabilities	$	3,719	$	3,284

Non-current assets include a long-term deferred tax asset. Liabilities consist of a lease guarantee commitment.

- Definition

The entire disclosure for the facts and circumstances leading to the completed or expected disposal, manner and timing of disposal, the gain (loss) recognized in the income statement and the income statement caption that includes that gain (loss), amounts of revenues and pretax profit or loss reported in discontinued operations, the segment in which the disposal group was reported, and the classification (whether sold or classified as held for sale) and carrying value of the assets and liabilities comprising the disposal group. Includes all disposal groups, including those classified as components of the entity (discontinued operations).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 144
-Paragraph 43-48
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

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+ Details

Subsequent Events

9 Months Ended

Sep. 24, 2011

Subsequent Events

Subsequent Events

15. Subsequent Events

Our biopharmaceutical clients are increasingly focused on efficacy testing and eliminating molecules earlier in the drug development process, which has led to continuing softness in demand for safety assessment testing. In order to align our infrastructure to the evolving demand dynamics, in the fourth quarter of 2011, we are implementing a headcount reduction of approximately 2%, primarily in the PCS business. This action is expected to generate annual savings of approximately $7,500 beginning in 2012. We anticipate recording severance and other costs of approximately $3,500 in the fourth-quarter of 2011.

Restructuring and Contract Termination Costs (Tables)

9 Months Ended

Sep. 24, 2011

Restructuring and Contract Termination Costs

Schedule of severance and retention costs

		Nine Months Ended

Severance and Retention Costs		September 24, 2011			September 25, 2010
Beginning balance		$	10,658		$	4,332
Expense			1,317			5,571
Payments/utilization			(7,625	)		(6,317	)

	Ending balance	$	4,350		$	3,586

Supplemental Balance Sheet Information (Tables)

9 Months Ended

Sep. 24, 2011

Supplemental Balance Sheet Information

Composition of trade receivables

		September 24, 2011			December 25, 2010

Customer receivables		$	176,257		$	170,696
Unbilled revenue			30,482			27,095

Total			206,739			197,791
Less allowance for doubtful accounts			(4,360	)		(4,819	)

	Net trade receivables	$	202,379		$	192,972

Composition of inventories

		September 24, 2011		December 25, 2010

Raw materials and supplies		$	12,715	$	13,153
Work in process			16,624		13,869
Finished products			65,052		73,275

	Inventories	$	94,391	$	100,297

Composition of other current assets

		September 24, 2011		December 25, 2010

Prepaid assets		$	20,889	$	21,434
Deferred tax asset			28,521		31,251
Marketable securities			6,188		9,834
Prepaid income tax			22,512		13,856
Restricted cash			229		228
Current assets of discontinued businesses			—		3,862

	Other current assets	$	78,339	$	80,465

Composition of net property, plant and equipment

		September 24, 2011			December 25, 2010

Land		$	40,610		$	40,409
Buildings			695,480			694,342
Machinery and equipment			345,706			327,353
Leasehold improvements			30,418			26,772
Furniture and fixtures			10,639			10,473
Vehicles			5,475			5,456
Computer hardware and software			105,976			106,073
Construction in progress			44,845			45,465

	Total		1,279,149			1,256,343
Less accumulated depreciation			(550,262	)		(503,686	)

Net property, plant and equipment		$	728,887		$	752,657

Composition of other assets

		September 24, 2011		December 25, 2010

Deferred financing costs		$	10,263	$	11,167
Cash surrender value of life insurance policies			24,174		31,054
Long-term marketable securities			11,070		11,377
Other assets			10,425		8,725
Long-term assets of discontinued businesses			1,121		822

	Other assets	$	57,053	$	63,145

Composition of other current liabilities

		September 24, 2011		December 25, 2010

Accrued income taxes		$	8,416	$	18,372
Current deferred tax liability			1,071		963
Accrued interest and other			3,492		760
Current liabilities of discontinued businesses			1,129		3,284

	Other current liabilities	$	14,108	$	23,379

Composition of other long-term liabilities

		September 24, 2011		December 25, 2010

Deferred tax liability		$	19,591	$	30,050
Long-term pension liability			28,947		36,335
Accrued Executive Supplemental Life Insurance Retirement Plan and Deferred Compensation Plan			25,446		24,659
Other long-term liabilities			23,105		23,552
Long-term liabilities of discontinued businesses			2,590		—

	Other long-term liabilities	$	99,679	$	114,596

Marketable Securities (Tables)

9 Months Ended

Sep. 24, 2011

Marketable Securities

Schedule of marketable securities by major security type

	September 24, 2011

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Time deposits	$	6,188	$	—	$	—		$	6,188
Auction rate securities		11,972		—		(902	)		11,070

	$	18,160	$	—	$	(902	)	$	17,258

	December 25, 2010

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Time deposits	$	9,834	$	—	$	—		$	9,834
Auction rate securities		11,974		—		(597	)		11,377

	$	21,808	$	—	$	(597	)	$	21,211

Schedule of maturities of debt securities

	September 24, 2011				December 25, 2010

	Amortized Cost		Fair Value		Amortized Cost		Fair Value
Due less than one year	$	6,188	$	6,188	$	9,834	$	9,834
Due after one year through five years		—		—		—		—
Due after ten years		11,972		11,070		11,974		11,377

	$	18,160	$	17,258	$	21,808	$	21,211

Fair Value (Tables)

9 Months Ended

Sep. 24, 2011

Fair Value

Summary of assets and liabilities measured at fair value on a recurring basis

	Fair Value Measurements at September 24, 2011 using

	Quoted Prices in Active Markets for Identical Assets Level 1		Significant Other Observable Inputs Level 2			Significant Unobservable Inputs Level 3		Assets at Fair Value
Time deposits	$	—	$	6,188		$	—	$	6,188
Auction rate securities		—		—			11,070		11,070
Fair value of life policies		—		18,690			—		18,690
Hedge contract		—		(45	)		—		(45	)

Total assets	$	—	$	24,833		$	11,070	$	35,903

Contingent consideration		—		—			4,392		4,392

Total liabilities	$	—	$	—		$	4,392	$	4,392

	Fair Value Measurements at December 25, 2010 using

	Quoted Prices in Active Markets for Identical Assets Level 1		Significant Other Observable Inputs Level 2		Significant Unobservable Inputs Level 3		Assets at Fair Value
Time deposits	$	—	$	9,834	$	—	$	9,834
Auction rate securities		—		—		11,377		11,377
Fair value of life policies		—		25,609		—		25,609
Hedge contract		—		419		—		419

Total assets	$	—	$	35,862	$	11,377	$	47,239

Contingent consideration		—		—		5,365		5,365

Total liabilities	$	—	$	—	$	5,365	$	5,365

Reconciliation of all assets and liabilities measured at fair value on a recurring basis using significant unobservable inputs (Level 3)

		Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

		Nine months ended
Auction rate securities		September 24, 2011			September 25, 2010
Beginning balance		$	11,377		$	16,212
Transfers in and/or out of Level 3			—			—
Total gains or losses (realized/unrealized):
	Included in earnings (other expenses)		(1	)		15
	Included in other comprehensive income		(306	)		574
Purchases, issuances and settlements			—			(5,500	)

Ending balance		$	11,070		$	11,301

		Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

		Nine months ended
Contingent consideration		September 24, 2011			September 25, 2010
Beginning balance		$	5,365		$	9,300
Transfers in and/or out of Level 3			—			—
Total gains or losses (realized/unrealized):
	Included in (earnings) other expenses		(973	)		(2,530	)
	Included in other comprehensive income		—			—
Purchases, issuances and settlements			—			—

Ending balance		$	4,392		$	6,770

Goodwill and Other Intangible Assets (Tables)

9 Months Ended

Sep. 24, 2011

Goodwill and Other Intangible Assets

Schedule of goodwill and other intangible assets not subject to amortization and other intangible assets that continue to be subject to amortization

		September 24, 2011							December 25, 2010

		Gross Carrying Amount		Accumulated Amortization & Impairment loss			Net Amount		Gross Carrying Amount		Accumulated Amortization & Impairment loss			Net Amount
Goodwill		$	1,216,569	$	(1,016,770	)	$	199,799	$	1,216,196	$	(1,017,758	)	$	198,438

Other intangible assets not subject to amortization:
	Research models	$	3,438	$	—		$	3,438	$	3,438	$	—		$	3,438
	PCS in process R&D		6,800		—			6,800		6,800		—			6,800
Other intangible assets subject to amortization:
	Backlog		2,942		(2,240	)		702		2,839		(2,109	)		730
	Customer relationships		292,263		(195,262	)		97,001		301,175		(192,345	)		108,830
	Customer contracts		15,259		(15,259	)		—		15,259		(15,259	)		—
	Trademarks and trade names		4,649		(4,649	)		—		5,041		(4,614	)		427
	Standard operating procedures		657		(657	)		—		657		(657	)		—
	Other identifiable intangible assets		4,300		(4,300	)		—		5,428		(4,417	)		1,011

Total other intangible assets		$	328,308	$	(222,367	)	$	105,941	$	340,637	$	(219,401	)	$	121,236

Schedule of changes in the gross carrying amount and accumulated amortization of goodwill

					Adjustments to Goodwill

		Balance at December 25, 2010			Acquisitions		Foreign Exchange/ Other			Balance at September 24, 2011
Research Models and Services
	Gross carrying amount	$	57,876		$	—	$	(996	)	$	56,880
	Accumulated amortization		(4,768	)		—		1,000			(3,768	)
Preclinical Services
	Gross carrying amount		1,158,320			—		1,369			1,159,689
	Accumulated impairment loss		(1,005,000	)		—		—			(1,005,000	)
	Accumulated amortization		(7,990	)		—		(13	)		(8,003	)
Total
	Gross carrying amount	$	1,216,196		$	—	$	373		$	1,216,569
	Accumulated impairment loss		(1,005,000	)		—		—			(1,005,000	)
	Accumulated amortization		(12,758	)		—		988			(11,770	)

- Definition

Tabular disclosure of goodwill by reportable segment and in total. Disclosure details may include, but are not limited to, the carrying amount of goodwill, goodwill acquired during the year, goodwill impairment losses recognized, goodwill written-off due to the sale of a business unit, goodwill not yet allocated, and any other changes to goodwill.

+ References + Details

Long-Term Debt (Tables)

9 Months Ended

Sep. 24, 2011

Long-Term Debt

Components of long-term debt

		September 24, 2011			December 25, 2010

2.25% Senior convertible debentures:
	Principal	$	349,995		$	349,995
	Unamortized debt discount		(25,317	)		(35,583	)

Net carrying amount of senior convertible debentures			324,678			314,412
Term loan facilities			393,465			386,213
Revolving credit facility			22,000			—
Other debt, represents secured and unsecured promissory notes, interest rates ranging from 0% to .5% and 0% to 0.5% at September 24, 2011 and December 25, 2010, respectively, maturing between 2011 and 2012			123			127

Total debt			740,266			700,752
Capital leases			55			100

Total debt and capital leases			740,321			700,852
Less: current portion of long-term debt and capital leases			(19,838	)		(30,582	)

Long-term debt and capital leases		$	720,483		$	670,270

Schedule of principal maturities of existing debt excluding unamortized debt discount

Twelve months ending

September 2012		$	19,796
September 2013			379,505
September 2014			54,102
September 2015			73,775
September 2016			238,405

	Total	$	765,583

Equity (Tables)

9 Months Ended

Sep. 24, 2011

Equity

Reconciliation of the numerator and denominator in the computations of the basic and diluted earnings per share

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Numerator:
Income (loss) from continuing operations for purposes of calculating earnings per share		$	18,816		$	(23,955	)	$	88,146		$	9,358
Loss from discontinued businesses		$	(18	)	$	(986	)	$	(5,695	)	$	(2,463	)
Denominator:
Weighted average shares outstanding—Basic			50,084,850			62,597,055			51,671,559			64,344,970
Effect of dilutive securities:
	2.25% senior convertible debentures		—			—			—			—
	Stock options and contingently issued restricted stock		448,897			—			566,868			549,855
	Warrants		—			—			—			—

Weighted average shares outstanding—Diluted			50,533,747			62,597,055			52,238,427			64,894,825

Basic earnings per share from continuing operations		$	0.38		$	(0.38	)	$	1.71		$	0.15
Basic loss per share from discontinued operations			—		$	(0.02	)	$	(0.11	)	$	(0.04	)
Diluted earnings per share from continuing operations		$	0.37		$	(0.38	)	$	1.69		$	0.14
Diluted loss per share from discontinued operations			—		$	(0.02	)	$	(0.11	)	$	(0.04	)

Schedule of number of shares repurchased and the total cost of repurchase

	Nine Months Ended

	September 24, 2011		September 25, 2010
Number of shares of common stock repurchased		7,663,863		8,607,157
Total cost of repurchase	$	277,420	$	254,998

Schedule of changes in equity

		Nine Months Ended

		September 24, 2011								September 25, 2010
		Shareowners' Equity			Noncontrolling Interest		Total Equity			Shareowners' Equity			Noncontrolling Interest			Total Equity
Equity, beginning of the period		$	687,423		$	1,304	$	688,727		$	1,375,243		$	(1,419	)	$	1,373,824
Components of comprehensive income, net of tax:
	Net income		82,451			298		82,749			6,895			(1,034	)		5,861
	Foreign currency translation adjustment		(7,834	)		56		(7,778	)		(9,818	)		(81	)		(9,899	)
	Amortization of pension, net gain/loss and prior service cost		483			—		483			260			—			260
	Unrealized loss on marketable securities		(305	)		—		(305	)		775			—			775

Total comprehensive income			74,795			354		75,149			(1,888	)		(1,115	)		(3,003	)
	Dividends paid noncontrolling interest		—			—		—			—			(270	)		(270	)
	Tax detriment associated with stock issued under employee compensation plans		(1,110	)		—		(1,110	)		(538	)		—			(538	)
	Issuance of stock under employee compensation plans		20,478			—		20,478			3,133			—			3,133
	Acquisition of treasury shares		(244,654	)		—		(244,654	)		(254,998	)		—			(254,998	)
	Acquisition of ASR equity instrument		(14,140	)		—		(14,140	)		(101,423	)		—			(101,423	)
	Stock-based compensation		16,919			—		16,919			21,443			—			21,443

Equity, end of the period		$	539,711		$	1,658	$	541,369		$	1,040,972		$	(2,804	)	$	1,038,168

Income Taxes (Tables)

9 Months Ended

Sep. 24, 2011

Income Taxes

Reconciliation of provision for income taxes on condensed consolidated statements of operations

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Income before income taxes	$	24,541		$	(7,578	)	$	100,008		$	38,901
Effective tax rate		22.9	%		(220.0	)%		11.6	%		78.6	%
Provision for income taxes	$	5,630		$	16,670		$	11,564		$	30,577

Employee Benefits (Tables)

9 Months Ended

Sep. 24, 2011

Pension Benefits

Employee benefits

Components of net periodic benefit cost for defined benefit plans

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Service cost		$	758		$	793		$	2,279		$	1,906
Interest cost			3,016			2,903			9,056			8,398
Expected return on plan assets			(3,407	)		(3,165	)		(10,213	)		(9,295	)
Amortization of prior service cost			(155	)		(148	)		(466	)		(447	)
Amortization of net loss (gain)			239			178			693			534

	Net periodic benefit cost	$	451		$	561		$	1,349		$	1,096

Company contributions		$	1,100		$	1,913		$	7,119		$	5,536

Supplemental Retirement Benefits

Employee benefits

Components of net periodic benefit cost for defined benefit plans

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Service cost		$	159	$	149	$	477	$	447
Interest cost			300		335		901		1,005
Amortization of prior service cost			125		124		374		374
Amortization of net loss (gain)			53		38		158		114

	Net periodic benefit cost	$	637	$	646	$	1,910	$	1,940

Stock-Based Compensation (Tables)

9 Months Ended

Sep. 24, 2011

Stock-Based Compensation

Schedule of stock-based compensation expense

		Three Months Ended						Nine Months Ended

		September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Stock-based compensation expense in:
	Cost of sales	$	1,626		$	1,838		$	5,003		$	6,088
	Selling and administration		3,945			4,933			11,916			15,355

	Income before income taxes		5,571			6,771			16,919			21,443
	Provision for income taxes		(1,991	)		(2,441	)		(6,050	)		(7,760	)

Net income attributable to common shareowners		$	3,580		$	4,330		$	10,869		$	13,683

Schedule of weighted-average assumptions

	Options Granted In:

	2011			2010
Expected life (in years)		4.2			4.5
Expected volatility		33.4	%		34.0	%
Risk-free interest rate		2.22	%		2.35	%
Expected dividend yield		0.0	%		0.0	%
Weighted-average grant date fair value	$	11.35		$	11.96

Summary of stock option activity in equity incentive plans

			Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value

Options outstanding as of December 25, 2010	6,594,313		$	37.87
Options granted	950,190		$	37.38
Options exercised	(719,489	)	$	28.46
Options canceled	(669,454	)	$	43.77

Options outstanding as of September 24, 2011	6,155,560		$	38.25	3.96 years	$	5,769

Options exercisable as of September 24, 2011	3,610,841		$	40.58	2.94 years	$	2,424

Summary of restricted stock activity

				Weighted-Average Grant Date Fair Value

Outstanding December 25, 2010		777,740		$	35.97
	Granted	284,480		$	37.30
	Vested	(295,457	)	$	37.64
	Canceled	(61,101	)	$	37.84

Outstanding September 24, 2011		705,662		$	35.64

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References + Details

Business Segment Information (Tables)

9 Months Ended

Sep. 24, 2011

Business Segment Information

Schedule of sales and other financial information by business segment

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Research Models and Services
	Net sales	$	171,471	$	159,259	$	523,005	$	498,604
	Gross margin		70,514		64,383		222,660		210,008
	Operating income		48,534		42,817		155,967		140,059
	Depreciation and amortization		9,327		9,422		27,914		27,954
	Capital expenditures		5,789		4,622		14,202		15,827
Preclinical Services
	Net sales	$	106,108	$	111,626	$	328,680	$	353,160
	Gross margin		22,202		26,117		79,014		81,447
	Operating income		3,663		5,178		20,844		12,116
	Depreciation and amortization		11,840		14,063		36,334		42,036
	Capital expenditures		2,433		4,505		7,470		11,025

Reconciliation of segment operating income to consolidated operating income

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Total segment operating income	$	52,197		$	47,995		$	176,811		$	152,175
Unallocated corporate overhead		(15,103	)		(11,527	)		(44,152	)		(55,528	)
Termination fee		—			(30,000	)		—			(30,000	)

Consolidated operating income	$	37,094		$	6,468		$	132,659		$	66,647

Schedule of net sales for each significant service area

		Three Months Ended				Nine Months Ended

		September 24, 2011		September 25, 2010		September 24, 2011		September 25, 2010
Research models		$	86,386	$	84,234	$	269,976	$	267,690
Research model services			54,539		50,575		161,936		153,536
Other products			30,546		24,450		91,093		77,378

	Total research models		171,471		159,259		523,005		498,604
	Total preclinical services		106,108		111,626		328,680		353,160

Total sales		$	277,579	$	270,885	$	851,685	$	851,764

Summary of unallocated corporate overhead

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Stock-based compensation expense	$	2,825		$	3,249		$	8,339		$	9,864
U.S. retirement plans		501			1,162			2,613			2,819
Audit, tax and related expenses		855			659			2,115			1,858
Salary and bonus		3,187			4,144			12,522			13,443
Global IT		3,089			3,373			9,623			9,950
Employee health and fringe cost		(2,307	)		(1,776	)		7			(800	)
Consulting and professional services		2,628			1,315			6,160			6,197
Depreciation		1,569			1,558			4,743			4,199
Transaction (acquisition/disposition) costs		251			(810	)		565			6,587
Life insurance death benefit gain		—			—			(7,710	)		—
Other general unallocated corporate expenses		2,505			(1,347	)		5,175			1,411

	$	15,103		$	11,527		$	44,152		$	55,528

- Definition

Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

+ References + Details

Discontinued Operations (Tables)

9 Months Ended

Sep. 24, 2011

Discontinued Operations

Schedule of operating results from discontinued operations

	Three Months Ended						Nine Months Ended

	September 24, 2011			September 25, 2010			September 24, 2011			September 25, 2010
Net sales	$	—		$	5,196		$	2,122		$	13,766
Income (loss) from operations of discontinued businesses, before income taxes		24			(1,354	)		(8,129	)		(3,727	)
Provision (benefit) for income taxes		42			(368	)		(2,434	)		(1,264	)

Loss from operations of discontinued businesses, net of taxes	$	(18	)	$	(986	)	$	(5,695	)	$	(2,463	)

Schedule of assets and liabilities of discontinued operations

		September 24, 2011		December 25, 2010

Current assets		$	—	$	3,862
Non-current assets			1,121		822

	Total assets	$	1,121	$	4,684

Current liabilities		$	1,129	$	3,284
Non-current liabilities			2,590		—

	Total liabilities	$	3,719	$	3,284

Restructuring and Contract Termination Costs (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 24, 2011	Sep. 25, 2010
Restructuring and Contract Termination Costs
Accrued severance and retention costs included in accrued compensation	$ 1,932
Accrued severance and retention costs included in other long-term liabilities	2,418
Severance charges included in cost of sales	437
Severance charges included in selling, general and administrative expense	880
Impairment charges	970
Severance and Retention Costs
Balance at the beginning of the period	10,658	$ 4,332
Expense	1,317	5,571
Payments/utilization	(7,625)	(6,317)
Balance at the end of the period	$ 4,350	$ 3,586

Supplemental Balance Sheet Information (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 24, 2011	Sep. 25, 2010	Dec. 25, 2010
Composition of trade receivables
Customer receivables	$ 176,257		$ 170,696
Unbilled revenue	30,482		27,095
Total	206,739		197,791
Less allowance for doubtful accounts	(4,360)		(4,819)
Net trade receivables	202,379		192,972
Composition of inventories
Raw materials and supplies	12,715		13,153
Work in process	16,624		13,869
Finished products	65,052		73,275
Inventories	94,391		100,297
Composition of other current assets
Prepaid assets	20,889		21,434
Deferred tax asset	28,521		31,251
Marketable securities	6,188		9,834
Prepaid income tax	22,512		13,856
Restricted cash	229		228
Current assets of discontinued businesses			3,862
Other current assets	78,339		80,465
Net property, plant and equipment
Gross property, plant and equipment	1,279,149		1,256,343
Less accumulated depreciation	(550,262)		(503,686)
Net property, plant and equipment	728,887		752,657
Depreciation expense	47,795	$ 51,744
Composition of other assets
Deferred financing costs	10,263		11,167
Cash surrender value of life insurance policies	24,174		31,054
Long-term marketable securities	11,070		11,377
Other assets	10,425		8,725
Long-term assets of discontinued businesses	1,121		822
Other assets	57,053		63,145
Composition of other current liabilities
Accrued income taxes	8,416		18,372
Current deferred tax liability	1,071		963
Accrued interest and other	3,492		760
Current liabilities of discontinued businesses	1,129		3,284
Other current liabilities	14,108		23,379
Composition of other long-term liabilities
Deferred tax liability	19,591		30,050
Long-term pension liability	28,947		36,335
Accrued Executive Supplemental Life Insurance Retirement Plan and Deferred Compensation Plan	25,446		24,659
Other long-term liabilities	23,105		23,552
Long-term liabilities of discontinued businesses	2,590
Other long-term liabilities, Total	99,679		114,596
Land
Net property, plant and equipment
Gross property, plant and equipment	40,610		40,409
Buildings
Net property, plant and equipment
Gross property, plant and equipment	695,480		694,342
Machinery and equipment
Net property, plant and equipment
Gross property, plant and equipment	345,706		327,353
Leasehold improvements
Net property, plant and equipment
Gross property, plant and equipment	30,418		26,772
Furniture and fixtures
Net property, plant and equipment
Gross property, plant and equipment	10,639		10,473
Vehicles
Net property, plant and equipment
Gross property, plant and equipment	5,475		5,456
Computer hardware and software
Net property, plant and equipment
Gross property, plant and equipment	105,976		106,073
Construction in progress
Net property, plant and equipment
Gross property, plant and equipment	$ 44,845		$ 45,465

Marketable Securities (Details) $ in Thousands	9 Months Ended
Marketable Securities (Details) $ in Thousands	Sep. 24, 2011 USD ($) Y day	Dec. 25, 2010 USD ($)
Marketable securities
Amortized Cost	$ 18,160	$ 21,808
Gross Unrealized Losses	(902)	(597)
Fair Value	17,258	21,211
Maturities of debt securities, Amortized Cost
Due less than one year, Amortized Cost	6,188	9,834
Due after ten years, Amortized Cost	11,972	11,974
Amortized Cost	18,160	21,808
Maturities of debt securities, Fair Value
Due less than one year, Fair Value	6,188	9,834
Due after ten years, Fair Value	11,070	11,377
Fair Value	17,258	21,211
Time deposits
Marketable securities
Amortized Cost	6,188	9,834
Fair Value	6,188	9,834
Maturities of debt securities, Fair Value
Fair Value	6,188	9,834
Auction rate securities
Marketable securities
Amortized Cost	11,972	11,974
Gross Unrealized Losses	(902)	(597)
Fair Value	11,070	11,377
Variable rate debt instruments	$ 11,070
Interest rate reset period for variable rate demand notes (in days) \| day	35
Contractual maturity minimum (in years) \| Y	10
Maturities of debt securities, Fair Value
Fair Value	$ 11,070	$ 11,377

Fair Value (Details) € in Thousands, $ in Thousands, $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Jun. 30, 2011 USD ($)	Sep. 24, 2011 USD ($)	Jun. 25, 2011 USD ($)	Sep. 24, 2011 USD ($) subsidiaries	Dec. 25, 2010 USD ($)	Sep. 14, 2010 CAD ($)	Sep. 14, 2010 EUR (€)
Fair market value hedge contract
Notional amount of Canadian dollars purchased						$ 62,637
Notional amount of Euros sold \| €							€ 46,940
Settlement amount on termination of hedge	$ 4,008
Number of subsidiaries for which entity entered into forward foreign currency contract to hedge foreign exchange impact of intercompany loan \| subsidiaries				2
Proceeds from life insurance policies related to a former officer			$ 9,500
Tax exempt gain from life insurance policies		$ 7,710	7,710
Reduction amount of fair value of the contingent consideration attributable to the acquisition of the Systems Pathology Company, LLC (SPC)			$ 1,206
Assets and liabilities measured at fair value on a recurring basis
Fair value of life policies		24,174		$ 24,174	$ 31,054
Contingent consideration probability adjustment rate, low end of range (as a percent)				5.00%
Contingent consideration probability adjustment rate, high end of range (as a percent)				70.00%
Contingent consideration discount rate (as a percent)				18.00%
Recurring basis \| Significant Other Observable Inputs Level 2
Assets and liabilities measured at fair value on a recurring basis
Fair value of life policies		18,690		$ 18,690	25,609
Hedge contract		(45)		(45)	419
Total assets		24,833		24,833	35,862
Recurring basis \| Significant Other Observable Inputs Level 2 \| Time deposits
Assets and liabilities measured at fair value on a recurring basis
Total assets		6,188		6,188	9,834
Recurring basis \| Significant Unobservable Inputs Level 3
Fair market value hedge contract
Fair value of the contingent consideration attributable to the acquisition of the Systems Pathology Company, LLC (SPC)		4,392		4,392	5,365
Assets and liabilities measured at fair value on a recurring basis
Total assets		11,070		11,070	11,377
Contingent consideration		4,392		4,392	5,365
Total liabilities		4,392		4,392	5,365
Recurring basis \| Significant Unobservable Inputs Level 3 \| Auction rate securities
Assets and liabilities measured at fair value on a recurring basis
Total assets		11,070		11,070	11,377
Recurring basis \| Assets at Fair Value
Fair market value hedge contract
Fair value of the contingent consideration attributable to the acquisition of the Systems Pathology Company, LLC (SPC)		4,392		4,392	5,365
Assets and liabilities measured at fair value on a recurring basis
Fair value of life policies		18,690		18,690	25,609
Hedge contract		(45)		(45)	419
Total assets		35,903		35,903	47,239
Contingent consideration		4,392		4,392	5,365
Total liabilities		4,392		4,392	5,365
Recurring basis \| Assets at Fair Value \| Time deposits
Assets and liabilities measured at fair value on a recurring basis
Total assets		6,188		6,188	9,834
Recurring basis \| Assets at Fair Value \| Auction rate securities
Assets and liabilities measured at fair value on a recurring basis
Total assets		$ 11,070		$ 11,070	$ 11,377

Fair Value (Details 2) - USD ($) $ in Thousands	9 Months Ended
Fair Value (Details 2) - USD ($) $ in Thousands	Sep. 24, 2011	Sep. 25, 2010
Auction rate securities
Reconciliation of all assets measured at fair value on a recurring basis using significant unobservable inputs (Level 3)
Balance at the beginning of the period	$ 11,377	$ 16,212
Total gains or losses (realized/unrealized) Included in earnings (other expenses)	(1)	15
Total gains or losses (realized/unrealized) Included in comprehensive income	(306)	574
Purchases, issuances and settlements		(5,500)
Balance at the end of the period	11,070	11,301
Contingent Consideration
Reconciliation of all liabilities measured at fair value on a recurring basis using significant unobservable inputs (Level 3)
Balance at the beginning of the period	5,365	9,300
Total gains or losses (realized/unrealized) Included in (earnings) other expenses	(973)	(2,530)
Balance at the end of the period	$ 4,392	$ 6,770

Goodwill and Other Intangible Assets (Details) - USD ($) $ in Thousands	Sep. 24, 2011	Dec. 25, 2010
Goodwill
Gross Carrying Amount	$ 1,216,569	$ 1,216,196
Accumulated Amortization And Impairment Loss	(1,016,770)	(1,017,758)
Net Amount	199,799	198,438
Other intangible assets
Other intangible assets, Gross Carrying Amount	328,308	340,637
Other intangible assets, Accumulated Amortization & Impairment loss	(222,367)	(219,401)
Other intangible assets, Net Amount	105,941	121,236
Backlog
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	2,942	2,839
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(2,240)	(2,109)
Other intangible assets subject to amortization, Net Amount	702	730
Customer relationships
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	292,263	301,175
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(195,262)	(192,345)
Other intangible assets subject to amortization, Net Amount	97,001	108,830
Customer contracts
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	15,259	15,259
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(15,259)	(15,259)
Trademarks and trade names
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	4,649	5,041
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(4,649)	(4,614)
Other intangible assets subject to amortization, Net Amount		427
Standard operating procedures
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	657	657
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(657)	(657)
Other identifiable intangible assets
Other intangible assets subject to amortization:
Other intangible assets subject to amortization, Gross Carrying Amount	4,300	5,428
Other intangible assets subject to amortization, Accumulated Amortization & Impairment loss	(4,300)	(4,417)
Other intangible assets subject to amortization, Net Amount		1,011
Research models.
Other intangible assets not subject to amortization:
Other intangible assets not subject to amortization, Gross Carrying Amount	3,438	3,438
Other intangible assets not subject to amortization, Net Amount	3,438	3,438
PCS in process R&D
Other intangible assets not subject to amortization:
Other intangible assets not subject to amortization, Gross Carrying Amount	6,800	6,800
Other intangible assets not subject to amortization, Net Amount	$ 6,800	$ 6,800

Goodwill and Other Intangible Assets (Details 2) $ in Thousands	9 Months Ended
	Sep. 24, 2011 USD ($)
Changes in gross carrying amount and accumulated amortization of goodwill
Gross carrying amount, balance at the beginning of the period	$ 1,216,196
Foreign exchange/Other	373
Gross carrying amount, balance at the end of the period	1,216,569
Accumulated amortization, balance at the beginning of the period	(12,758)
Foreign exchange/Other	(988)
Accumulated amortization, balance at the end of the period	(11,770)
Accumulated impairment loss, balance at the beginning of the period	(1,005,000)
Accumulated impairment loss, balance at the end of the period	(1,005,000)
Research Models and Services
Changes in gross carrying amount and accumulated amortization of goodwill
Gross carrying amount, balance at the beginning of the period	57,876
Foreign exchange/Other	(996)
Gross carrying amount, balance at the end of the period	56,880
Accumulated amortization, balance at the beginning of the period	(4,768)
Foreign exchange/Other	(1,000)
Accumulated amortization, balance at the end of the period	(3,768)
Preclinical Services
Changes in gross carrying amount and accumulated amortization of goodwill
Gross carrying amount, balance at the beginning of the period	1,158,320
Foreign exchange/Other	1,369
Gross carrying amount, balance at the end of the period	1,159,689
Accumulated amortization, balance at the beginning of the period	(7,990)
Foreign exchange/Other	(13)
Accumulated amortization, balance at the end of the period	(8,003)
Accumulated impairment loss, balance at the beginning of the period	(1,005,000)
Accumulated impairment loss, balance at the end of the period	$ (1,005,000)

Long-Term Debt (Details) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
Long-Term Debt (Details) - USD ($) $ in Thousands	Sep. 24, 2011	Dec. 25, 2010
Debt Instrument
Principal	$ 765,583
Total debt	740,266	$ 700,752
Capital leases	55	100
Total debt and capital leases	740,321	700,852
Less: current portion of long-term debt and capital leases	(19,838)	(30,582)
Long-term debt and capital leases	$ 720,483	670,270
Interest rate on debt (as a percent)	0.00%
2.25% Senior convertible debentures
Debt Instrument
Principal	$ 349,995	349,995
Unamortized debt discount	(25,317)	(35,583)
Total debt	$ 324,678	314,412
Interest rate on debt (as a percent)	2.25%
Term loan facilities
Debt Instrument
Total debt	$ 393,465	386,213
Revolving credit facility
Debt Instrument
Total debt	22,000
Other debt, representing secured and unsecured promissory notes, interest rates ranging from 0% to 0.5% at June 25, 2011 and December 25, 2010 maturing between 2011 and 2012
Debt Instrument
Total debt	$ 123	$ 127
Interest rate on debt, minimum (as a percent)	0.00%	0.00%
Interest rate on debt, maximum (as a percent)	0.50%	0.50%

Long-Term Debt (Details 2) $ / shares in Units, € in Thousands	3 Months Ended				9 Months Ended
	Sep. 23, 2012 numerator denominator	Jun. 24, 2012 numerator denominator	Sep. 24, 2011 USD ($) $ / shares	Sep. 25, 2010 USD ($)	Sep. 24, 2011 USD ($) shares numerator denominator quarter day month Payment $ / shares	Sep. 25, 2010 USD ($)	Sep. 24, 2011 EUR (€)	Feb. 28, 2011 USD ($)	Dec. 25, 2010 USD ($)	Dec. 25, 2010 EUR (€)
Debt Instrument
Amount of equity component of convertible debt			$ 25,317,000		$ 25,317,000
Principal maturities of existing debt excluding unamortized debt discount
June 2012			19,796,000		19,796,000
June 2013			379,505,000		379,505,000
June 2014			54,102,000		54,102,000
June 2015			73,775,000		73,775,000
June 2016			238,405,000		238,405,000
Total			765,583,000		765,583,000
2.25% Senior convertible debentures
Debt Instrument
Face amount of debt			350,000,000		$ 350,000,000
Initial conversion rate of common stock per $1000 of principal amount of Convertible Notes (in shares) \| shares					20.4337
Principal amount used for debt instrument conversion ratio			$ 1,000		$ 1,000
Initial conversion price of convertible notes into common stock (in dollars per share) \| $ / shares			$ 48.94		$ 48.94
Number of days within 30 consecutive trading days in which the closing price of the entity's common stock must exceed the conversion price for the notes to be redeemable \| day					20
Number of consecutive trading days during which the closing price of the entity's common stock must exceed the conversion price for at least 20 days in order for the notes to be redeemable \| day					30
Percentage of the closing sales price of the entity's common stock that the conversion price must exceed in order for the notes to be convertible (as a percent)					130.00%
Number of consecutive business days immediately after any five consecutive trading day period during the note measurement period \| day					5
Number of consecutive trading days before five consecutive business days during the note measurement period \| day					5
Percentage of the trading price to the product of the last reported sale price of the entity's common stock and the conversion rate, maximum (as a percent)					98.00%
Number of months prior to the stated maturity date that the debt instrument is convertible at the option of the holder \| month					2
Percentage of principal amount at which notes may be required to be repurchased in event of fundamental change by the entity (as a percent)					100.00%
Fair value			$ 343,940,000		$ 343,940,000
Unamortized debt discount			25,317,000		$ 25,317,000				$ 35,583,000
Amortization period of debt discount (in quarters) \| quarter					7
Amount of equity component of convertible debt			88,492,000		$ 88,492,000				88,492,000
Interest expense related to convertible debt			$ 3,514,000	$ 3,349,000	$ 10,266,000	$ 9,664,000
Effective interest rate (as a percent)			6.93%		6.93%		6.93%
Contractual interest expense recognized on convertible debt			$ 1,969,000	$ 1,969,000	$ 5,906,000	$ 5,906,000
Principal maturities of existing debt excluding unamortized debt discount
Total			349,995,000		349,995,000				349,995,000
Credit agreement
Debt Instrument
Maximum borrowing capacity under the credit agreement before amendment									750,000,000
Increase in the credit agreement's borrowing capacity available under specified circumstances			$ 250,000,000		$ 250,000,000
Percentage of capital stock of domestic subsidiaries (excluding disregarded entities) pledged as collateral for borrowings (as a percent)			100.00%		100.00%		100.00%
Percentage of capital stock of first-tier foreign subsidiaries and domestic subsidiaries treated as disregarded entities for U.S. federal income tax purposes pledged as collateral for borrowings (as a percent)			65.00%		65.00%		65.00%
Minimum book value on owned real property in the U.S. whose mortgages are pledged as collateral for borrowings			$ 10,000,000		$ 10,000,000
Number of consecutive quarters for which ratio of consolidated EBITDA less capital expenditures to consolidated cash interest expense is required to be maintained under financial covenants \| quarter					4
Numerator for ratio of consolidated EBITDA less capital expenditures to consolidated cash interest expense, minimum \| numerator					3.5
Denominator for ratio of consolidated EBITDA less capital expenditures to consolidated cash interest expense, minimum \| denominator					1
Number of consecutive quarters for which ratio of consolidated indebtedness to consolidated EBITDA is required to be maintained under financial covenants \| quarter					4
Numerator for the ratio of consolidated indebtedness to consolidated EBITDA, maximum \| numerator	3.25	3.5			4
Denominator for the ratio of consolidated indebtedness to consolidated EBITDA, maximum \| denominator	1	1			1
Outstanding under letters of credit			$ 4,475,000		$ 4,475,000
Credit agreement \| Base rate
Debt Instrument
Interest rate margin, low end of range (as a percent)					0.00%
Interest rate margin, high end of range (as a percent)					0.75%
Interest rate margin (as a percent)			0.75%		0.75%		0.75%
Credit agreement \| Federal funds rate
Debt Instrument
Interest rate margin (as a percent)			0.50%		0.50%		0.50%
Credit agreement \| One-month adjusted LIBOR rate
Debt Instrument
Interest rate margin (as a percent)			1.00%		1.00%		1.00%
Credit agreement \| LIBOR
Debt Instrument
Interest rate margin, low end of range (as a percent)					1.00%
Interest rate margin, high end of range (as a percent)					1.75%
Interest rate margin (as a percent)			1.75%		1.75%		1.75%
Term loan facilities
Debt Instrument
Number of quarterly installment payments \| Payment					20
Term loan
Debt Instrument
Maximum borrowing capacity			$ 299,750,000		$ 299,750,000
Maximum borrowing capacity under the credit agreement before amendment									230,000,000
Euro term loan
Debt Instrument
Maximum borrowing capacity \| €							€ 69,414
Maximum borrowing capacity under the credit agreement before amendment \| €										€ 133,762
Revolving credit facility
Debt Instrument
Maximum borrowing capacity			$ 350,000,000		$ 350,000,000
Maximum borrowing capacity under the credit agreement before amendment									$ 350,000,000
Incremental U.S. term loan
Debt Instrument
Maximum borrowing capacity								$ 150,000,000

Equity (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 24, 2011	Sep. 25, 2010	Sep. 24, 2011	Sep. 25, 2010
Numerator:
Income (loss) from continuing operations for purposes of calculating earnings per share (in dollars)	$ 18,816	$ (23,955)	$ 88,146	$ 9,358
Loss from discontinued operations, net of tax (in dollars)	$ (18)	$ (986)	$ (5,695)	$ (2,463)
Denominator:
Weighted average shares outstanding-Basic (in shares)	50,084,850	62,597,055	51,671,559	64,344,970
Effect of dilutive securities:
Stock options and contingently issued restricted stock (in shares)	448,897		566,868	549,855
Weighted average shares outstanding-Diluted (in shares)	50,533,747	62,597,055	52,238,427	64,894,825
Basic earnings per share from continuing operations (in dollars per share)	$ 0.38	$ (0.38)	$ 1.71	$ 0.15
Basic loss per share from discontinued operations (in dollars per share)		(0.02)	(0.11)	(0.04)
Diluted earnings per share from continuing operations (in dollars per share)	$ 0.37	(0.38)	1.69	0.14
Diluted loss per share from discontinued operations (in dollars per share)		$ (0.02)	$ (0.11)	$ (0.04)
Interest rate on debt (as a percent)	0.00%		0.00%
2.25% Senior convertible debentures
Effect of dilutive securities:
Interest rate on debt (as a percent)	2.25%		2.25%
Stock options
Antidilutive securities excluded from computation of earnings per share amount
Antidilutive securities excluded from computation of earnings per share amount (in shares)	4,253,703	5,112,792	4,245,953	4,363,966
Effect of dilutive securities:
Weighted average shares outstanding-Diluted (in shares)	705,662	873,126	705,662	873,126
Restricted stock
Effect of dilutive securities:
Weighted average shares outstanding-Diluted (in shares)		0

Equity (Details 2) $ in Thousands	1 Months Ended				3 Months Ended		9 Months Ended		12 Months Ended
Equity (Details 2) $ in Thousands	May 31, 2011 USD ($) shares	Feb. 28, 2011 USD ($) transaction shares	Oct. 31, 2010 USD ($)	Aug. 31, 2010 USD ($)	Sep. 24, 2011 USD ($) shares	Sep. 25, 2010 USD ($) shares	Sep. 24, 2011 USD ($) shares	Sep. 25, 2010 USD ($) shares	Dec. 25, 2010 shares	Feb. 24, 2011 USD ($)
Treasury Shares and Accelerated Stock Repurchase Program (ASR)
Authorized amount of stock repurchase			$ 750,000
Total cost of repurchase of treasury shares							$ 277,420	$ 254,998
Fair market value of treasury shares purchased							$ 244,654	$ 254,998
Number of shares of common stock repurchased (in shares) \| shares							7,663,863	8,607,157
Payments for Repurchase of Common Stock							$ 255,610	$ 356,421
Accelerated stock repurchase program entered into on February 24, 2011
Treasury Shares and Accelerated Stock Repurchase Program (ASR)
Authorized amount of stock repurchase		$ 150,000
Fair market value of treasury shares purchased	$ 257	$ 135,860
Number of shares of common stock repurchased (in shares) \| shares	6,505	3,759,398
Number of transactions recorded for repurchases under the stock repurchase program \| transaction		2
Forward contract indexed to common stock										$ 14,140
Payments for Repurchase of Common Stock		$ 150,000
Accelerated stock repurchase program entered into on August 26, 2010
Treasury Shares and Accelerated Stock Repurchase Program (ASR)
Authorized amount of stock repurchase				$ 300,000
Fair market value of treasury shares purchased		$ 32,509
Number of shares of common stock repurchased (in shares) \| shares		871,829							8,000,000
Payments for Repurchase of Common Stock				$ 300,000
Open market repurchases
Treasury Shares and Accelerated Stock Repurchase Program (ASR)
Total cost of repurchase of treasury shares							$ 105,852
Number of shares of common stock repurchased (in shares) \| shares							2,946,468
2000 Incentive Plan and 2007 Incentive Plan
Treasury Shares and Accelerated Stock Repurchase Program (ASR)
Fair market value of treasury shares purchased					$ 39	$ 568	$ 2,942	$ 3,533
Number of shares of common stock repurchased (in shares) \| shares					1,056	18,674	79,663	97,300

Equity (Details 3) $ in Thousands, shares in Millions	3 Months Ended		9 Months Ended
Equity (Details 3) $ in Thousands, shares in Millions	Sep. 24, 2011 USD ($) $ / shares shares	Sep. 25, 2010 USD ($)	Sep. 24, 2011 USD ($) increment $ / shares shares	Sep. 25, 2010 USD ($)
Equity
Warrants issued (in shares) \| shares	7.2		7.2
Exercise price of warrants (in dollars per share) \| $ / shares	59.925		59.925
Number of equal increments over which the warrants will expire between September 13, 2013 and January 22, 2014 \| increment			90
Proceeds from issuance of warrants			$ 65,423
Changes in equity
Balance			688,727	$ 1,373,824
Components of comprehensive income, net of tax:
Net income	$ 18,893	$ (25,234)	82,749	5,861
Foreign currency translation adjustment			(7,778)	(9,899)
Amortization of pension, net gain/loss and prior service cost			483	260
Unrealized loss on marketable securities			(305)	775
Total comprehensive income			75,149	(3,003)
Dividends paid noncontrolling interest				(270)
Tax detriment associated with stock issued under employee compensation plans			(1,110)	(538)
Issuance of stock under employee compensation plans			20,478	3,133
Acquisition of treasury shares			(244,654)	(254,998)
Acquisition of ASR equity instrument			(14,140)	(101,423)
Stock-based compensation			16,919	21,443
Balance	541,369	1,038,168	541,369	1,038,168
Shareowner's Equity
Changes in equity
Balance			687,423	1,375,243
Components of comprehensive income, net of tax:
Net income			82,451	6,895
Foreign currency translation adjustment			(7,834)	(9,818)
Amortization of pension, net gain/loss and prior service cost			483	260
Unrealized loss on marketable securities			(305)	775
Total comprehensive income			74,795	(1,888)
Tax detriment associated with stock issued under employee compensation plans			(1,110)	(538)
Issuance of stock under employee compensation plans			20,478	3,133
Acquisition of treasury shares			(244,654)	(254,998)
Acquisition of ASR equity instrument			(14,140)	(101,423)
Stock-based compensation			16,919	21,443
Balance	539,711	1,040,972	539,711	1,040,972
Noncontrolling Interest
Changes in equity
Balance			1,304	(1,419)
Components of comprehensive income, net of tax:
Net income			298	(1,034)
Foreign currency translation adjustment			56	(81)
Total comprehensive income			354	(1,115)
Dividends paid noncontrolling interest				(270)
Balance	$ 1,658	$ (2,804)	1,658	(2,804)
Comprehensive Income
Components of comprehensive income, net of tax:
Net income			82,749	5,861
Foreign currency translation adjustment			(7,778)	(9,899)
Amortization of pension, net gain/loss and prior service cost			483	260
Unrealized loss on marketable securities			(305)	775
Total comprehensive income			$ 75,149	$ (3,003)

Income Taxes (Details) $ in Thousands	3 Months Ended				9 Months Ended
Income Taxes (Details) $ in Thousands	Sep. 24, 2011 USD ($)	Mar. 26, 2011 USD ($)	Sep. 25, 2010 USD ($)	Jun. 26, 2010 USD ($)	Sep. 24, 2011 USD ($) month	Sep. 25, 2010 USD ($)
Income Taxes
Income before income taxes	$ 24,541		$ (7,578)		$ 100,008	$ 38,901
Effective tax rate (as a percent)	22.90%		220.00%		11.60%	78.60%
Provision for income taxes	$ 5,630		$ 16,670		$ 11,564	$ 30,577
Termination fee			30,000			$ 30,000
Change in indefinite reinvestment assertion			$ 205,400	$ 27,100
Tax exempt gain on the settlement of a life insurance policy					7,710
Income tax benefit associated with a tax loss incurred on the disposition of Phase I clinical business		$ 11,111
Tax exempt gain from German tax audit	1,366
Remeasurement of deferred taxes for decline in statutory tax rate in United Kingdom	486				486
Income tax expense related to repatriated earnings	747
Decrease in unrecognized tax benefits					7,780
Unrecognized tax benefits	27,517				27,517
Decrease in unrecognized tax benefits that would impact effective tax rate favorably, if recognized	7,731
Unrecognized tax benefits that would impact effective tax rate favorably, if recognized	22,182				$ 22,182
Maximum period within which it is reasonably possible that controversies with TCC and MRQ will conclude (in months) \| month					12
Decrease in amount of accrued interest on unrecognized tax benefits	1,099
Amount of accrued interest on unrecognized tax benefits	$ 1,409				$ 1,409

Employee Benefits (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
Employee Benefits (Details) - USD ($) $ in Thousands	Sep. 24, 2011	Sep. 25, 2010	Sep. 24, 2011	Sep. 25, 2010
Employee benefits
Expected contributions during the current fiscal year	$ 10,666		$ 10,666
Pension Benefits
Employee benefits
Service cost	758	$ 793	2,279	$ 1,906
Interest cost	3,016	2,903	9,056	8,398
Expected return on plan assets	(3,407)	(3,165)	(10,213)	(9,295)
Amortization of prior service cost	(155)	(148)	(466)	(447)
Amortization of net loss (gain)	239	178	693	534
Net periodic benefit cost	451	561	1,349	1,096
Company contributions	1,100	1,913	7,119	5,536
Supplemental Retirement Benefits
Employee benefits
Service cost	159	149	477	447
Interest cost	300	335	901	1,005
Amortization of prior service cost	125	124	374	374
Amortization of net loss (gain)	53	38	158	114
Net periodic benefit cost	$ 637	$ 646	$ 1,910	$ 1,940

Stock-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
Stock-Based Compensation (Details) - USD ($) $ in Thousands	Sep. 24, 2011	Sep. 25, 2010	Sep. 24, 2011	Sep. 25, 2010
Stock-based compensation
Stock-based compensation expense	$ 5,571	$ 6,771	$ 16,919	$ 21,443
Income tax benefit related to stock-based compensation expense	(1,991)	(2,441)	(6,050)	(7,760)
Stock-based compensation expense, net of income tax benefit	3,580	4,330	10,869	13,683
Cost of sales
Stock-based compensation
Stock-based compensation expense	1,626	1,838	5,003	6,088
Selling and administration
Stock-based compensation
Stock-based compensation expense	$ 3,945	$ 4,933	$ 11,916	$ 15,355

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References + Details

Stock-Based Compensation (Details 2) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 24, 2011 USD ($) Y $ / shares shares	Sep. 25, 2010 USD ($)	Sep. 24, 2011 USD ($) Y month $ / shares shares	Sep. 25, 2010 USD ($) Y $ / shares
Stock-based compensation weighted-average assumptions
Expected life (in years) \| Y			4.2	4.5
Expected volatility (as a percent)			33.40%	34.00%
Risk-free interest rate (as a percent)			2.22%	2.35%
Expected dividend yield (as a percent)			0.00%	0.00%
Weighted-average grant date fair value (in dollars per share)			$ 11.35	$ 11.96
Restricted stock activity, additional disclosures
Compensation expense \| $	$ 5,571	$ 6,771	$ 16,919	$ 21,443
Stock options.
Stock option activity, shares
Options outstanding, balance at the beginning of the period (in shares) \| shares			6,594,313
Options granted (in shares) \| shares			950,190
Options exercised (in shares) \| shares			(719,489)
Options canceled (in shares) \| shares			(669,454)
Options outstanding, balance at the end of the period (in shares) \| shares	6,155,560		6,155,560
Options exercisable, balance at the end of the period (in shares) \| shares	3,610,841		3,610,841
Stock option activity, weighted-average exercise price
Options outstanding, balance at the beginning of the period (in dollars per share)			$ 37.87
Options granted (in dollars per share)	$ 37.38		37.38
Options exercised (in dollars per share)	28.46		28.46
Options canceled (in dollars per share)	43.77		43.77
Options outstanding, balance at the end of the period (in dollars per share)	38.25		38.25
Options exercisable, balance at the end of the period (in dollars per share)	$ 40.58		$ 40.58
Stock option activity, weighted-average remaining contractual life
Options outstanding, balance at the end of the period (in years) \| Y	3.96		3.96
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm \| Y			2.94
Stock option activity, Aggregate Intrinsic Value
Options outstanding, balance at the end of the period \| $	$ 5,769		$ 5,769
Options exercisable, balance at the end of the period \| $	2,424		2,424
Stock option activity, additional disclosures
Intrinsic value of options exercised \| $	1,204	128	7,914	1,269
Amount of cash received from exercise of options \| $			20,574	3,118
Actual tax benefit realized for tax deductions from option exercises \| $			2,881	370
Charge recorded in capital in excess of par value for excess of deferred tax assets over actual tax benefits at option exercise \| $			1,110
Unrecognized compensation expense
Unrecognized compensation cost \| $	20,066		$ 20,066
Estimated weighted-average amortization period for unrecognized compensation cost (in months) \| month			30
Restricted stock
Unrecognized compensation expense
Unrecognized compensation cost \| $	$ 18,955		$ 18,955
Estimated weighted-average amortization period for unrecognized compensation cost (in months) \| month			30
Restricted stock activity, restricted stock
Balance at the beginning of the period (in shares) \| shares			777,740
Granted (in shares) \| shares			284,480
Vested (in shares) \| shares			(295,457)
Canceled (in shares) \| shares			(61,101)
Balance at the end of the period (in shares) \| shares	705,662		705,662
Restricted stock activity, weighted-average grant date fair value
Balance at the beginning of the period (in dollars per share)			$ 35.97
Granted (in dollars per share)			37.30
Vested (in dollars per share)			37.64
Canceled (in dollars per share)	$ 37.84		37.84
Balance at the end of the period (in dollars per share)	$ 35.64		$ 35.64
Restricted stock activity, additional disclosures
Fair value of restricted stock grants that vested \| $	$ 122	2,516	$ 10,985	12,510
Performance Based Stock Award Program
Restricted stock activity, additional disclosures
Compensation expense \| $	$ 54	$ 105	$ 162	$ 315

Business Segment Information (Details) $ in Thousands	3 Months Ended			9 Months Ended		12 Months Ended
Business Segment Information (Details) $ in Thousands	Sep. 24, 2011 USD ($)	Jun. 25, 2011 USD ($)	Sep. 25, 2010 USD ($)	Sep. 24, 2011 USD ($) segment	Sep. 25, 2010 USD ($)	Dec. 25, 2010 USD ($)
Business Segment Information
Number of reportable segments \| segment				2
Business segment information
Net sales	$ 277,579		$ 270,885	$ 851,685	$ 851,764
Operating income	37,094		6,468	132,659	66,647
Depreciation and amortization				64,249	69,990
Capital expenditures				21,672	26,853
Reconciliation of segment operating income to consolidated operating income
Operating income	37,094		6,468	132,659	66,647
Net sales for each significant service area
Total net sales	277,579		270,885	851,685	851,764
Unallocated corporate overhead
Stock-based compensation expense	5,571		6,771	16,919	21,443
Depreciation				47,795	51,744
Life insurance death benefit gain	(7,710)	$ (7,710)
Total
Business segment information
Operating income	52,197		47,995	176,811	152,175
Reconciliation of segment operating income to consolidated operating income
Operating income	52,197		47,995	176,811	152,175
Research Models and Services
Business segment information
Net sales	171,471		159,259	523,005	498,604
Gross margin	70,514		64,383	222,660	210,008
Operating income	48,534		42,817	155,967	140,059
Depreciation and amortization	9,327		9,422	27,914	27,954
Capital expenditures	5,789		4,622	14,202	15,827
Reconciliation of segment operating income to consolidated operating income
Operating income	48,534		42,817	155,967	140,059
Net sales for each significant service area
Total net sales	171,471		159,259	523,005	498,604
Research Models and Services \| Research models
Business segment information
Net sales	86,386		84,234	269,976	267,690
Net sales for each significant service area
Total net sales	86,386		84,234	269,976	267,690
Research Models and Services \| Research model services
Business segment information
Net sales	54,539		50,575	161,936	153,536
Net sales for each significant service area
Total net sales	54,539		50,575	161,936	153,536
Research Models and Services \| Other products
Business segment information
Net sales	30,546		24,450	91,093	77,378
Net sales for each significant service area
Total net sales	30,546		24,450	91,093	77,378
Preclinical Services
Business segment information
Net sales	106,108		111,626	328,680	353,160
Gross margin	22,202		26,117	79,014	81,447
Operating income	3,663		5,178	20,844	12,116
Depreciation and amortization	11,840		14,063	36,334	42,036
Capital expenditures	2,433		4,505	7,470	11,025
Reconciliation of segment operating income to consolidated operating income
Operating income	3,663		5,178	20,844	12,116
Net sales for each significant service area
Total net sales	106,108		111,626	328,680	353,160
Unallocated corporate overhead
Business segment information
Operating income	(15,103)		(11,527)	(44,152)	(55,528)
Reconciliation of segment operating income to consolidated operating income
Operating income	(15,103)		(11,527)	(44,152)	(55,528)
Unallocated corporate overhead
Stock-based compensation expense	2,825		3,249	8,339	9,864
U.S. retirement plans	501		1,162	2,613	2,819
Audit, tax and related expenses	855		659	2,115	1,858
Salaries and bonus	3,187		4,144	12,522	13,443
Global IT	3,089		3,373	9,623	9,950
Employee health and fringe cost	(2,307)		(1,776)	7	(800)
Consulting and professional services	2,628		1,315	6,160	6,197
Depreciation	1,569		1,558	4,743	4,199
Transaction (acquisition/disposition) costs	251		(810)	565	6,587
Life insurance death benefit gain				(7,710)
Other general unallocated corporate expenses	2,505		(1,347)	5,175	1,411
Total unallocated corporate overhead	$ 15,103		11,527	$ 44,152	$ 55,528
Termination fee
Business segment information
Operating income			(30,000)			$ (30,000)
Reconciliation of segment operating income to consolidated operating income
Operating income			$ (30,000)			$ (30,000)

Discontinued Operations (Details) - USD ($) $ in Thousands	3 Months Ended			9 Months Ended
Discontinued Operations (Details) - USD ($) $ in Thousands	Sep. 24, 2011	Mar. 26, 2011	Sep. 25, 2010	Sep. 24, 2011	Sep. 25, 2010	Jun. 25, 2011	Dec. 25, 2010
Operating results from discontinued operations
Provision (benefit) from income taxes		$ (11,111)
Loss from operations of discontinued businesses, net of taxes	$ (18)		$ (986)	$ (5,695)	$ (2,463)
Assets and liabilities of discontinued operations
Current assets							$ 3,862
Non-current assets	1,121			1,121			822
Current liabilities	1,129			1,129			3,284
Non-current liabilities	2,590			2,590
Phase I clinical business
Operating results from discontinued operations
Facility lease payments				15,060
Net sales			5,196	2,122	13,766
Income (loss) from operations of discontinued businesses, before income taxes	24		(1,354)	(8,129)	(3,727)
Provision (benefit) from income taxes	42		(368)	(2,434)	(1,264)
Loss from operations of discontinued businesses, net of taxes	(18)		$ (986)	(5,695)	$ (2,463)
Assets and liabilities of discontinued operations
Current assets							3,862
Non-current assets	1,121			1,121			822
Total assets	1,121			1,121			4,684
Current liabilities	1,129			1,129			3,284
Non-current liabilities	2,590			2,590		$ 2,994
Total liabilities	$ 3,719			$ 3,719			$ 3,284

Subsequent Events (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Subsequent Events (Details) - USD ($) $ in Thousands	Dec. 31, 2011	Sep. 24, 2011	Sep. 25, 2010
Subsequent Events
Severance		$ 1,317	$ 5,571
Employee Severance
Subsequent Events
Headcount reduction (as a percent)	2.00%
Annual savings in employee related costs	$ 7,500
Severance	$ 3,500

- Definition

The charge against earnings in the period for known and estimated costs of termination benefits provided to current employees that are involuntarily terminated under a benefit arrangement associated with exit from or disposal of business activities or restructurings pursuant to a duly authorized plan, excluding costs or losses pertaining to an entity newly acquired in a business combination or a discontinued operation as defined by generally accepted accounting principles and costs associated with one-time termination benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 5
-Section P
-Subsection 3, 4

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS146-1
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 132R
-Paragraph 5-8
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 112
-Paragraph 7
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 146
-Paragraph 8-13, 20
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 5.P.3)
-URI http://asc.fasb.org/extlink&oid=6394695&loc=d3e140864-122747

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 420
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB TOPIC 5.P.4(b))
-URI http://asc.fasb.org/extlink&oid=6394695&loc=d3e140904-122747

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 715
-SubTopic 20
-Section 50
-Paragraph 1
-Subparagraph (a)(10)
-URI http://asc.fasb.org/extlink&oid=6962843&loc=d3e1928-114920

+ Details

Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 24, 2011	Oct. 17, 2011
Document and Entity Information
Entity Registrant Name	CHARLES RIVER LABORATORIES INTERNATIONAL INC
Entity Central Index Key	0001100682
Document Type	10-Q
Document Period End Date	Sep. 24, 2011
Amendment Flag	false
Current Fiscal Year End Date	--12-25
Entity Current Reporting Status	Yes
Entity Filer Category	Large Accelerated Filer
Entity Common Stock, Shares Outstanding		49,440,569
Document Fiscal Year Focus	2011
Document Fiscal Period Focus	Q3