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  <xs:element id="crl_AccruedCompensationMember" abstract="true" name="AccruedCompensationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_SeniorNotesDue2028Member" abstract="true" name="SeniorNotesDue2028Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_BusinessCombinationDeferredPurchasePrice" abstract="false" name="BusinessCombinationDeferredPurchasePrice" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_FairValueMeasurementWithUnobservableInputsReconciliationWeightedAverageProbabilityOfMaximumTarget" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationWeightedAverageProbabilityOfMaximumTarget" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_IncrementalDividendsAttributedToNoncontrollingInterestHolders" abstract="false" name="IncrementalDividendsAttributedToNoncontrollingInterestHolders" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_FairValueContingentConsiderationTableTextBlock" abstract="false" name="FairValueContingentConsiderationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="crl_BusinessCombinationRedemptionPrice" abstract="false" name="BusinessCombinationRedemptionPrice" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBiologicalAssetsNoncurrent" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBiologicalAssetsNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_TradeReceivablesFromCustomers" abstract="false" name="TradeReceivablesFromCustomers" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_SeniorNotesDue2031Member" abstract="true" name="SeniorNotesDue2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_TermDepositFairValueDisclosure" abstract="false" name="TermDepositFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_ScheduleOfEquityMethodInvestmentsRollForward" abstract="true" name="ScheduleOfEquityMethodInvestmentsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_BusinessCombinationAdjustmentsForWorkingCapitalDebt" abstract="false" name="BusinessCombinationAdjustmentsForWorkingCapitalDebt" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_BusinessCombinationConsiderationLiabilityContingentUponFuturePerformance" abstract="false" name="BusinessCombinationConsiderationLiabilityContingentUponFuturePerformance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_StockRepurchasesLineItems" abstract="true" name="StockRepurchasesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_BiologicalAssetsUsefulLife" abstract="false" name="BiologicalAssetsUsefulLife" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crl_ShannonParisottoMember" abstract="true" name="ShannonParisottoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_OtherMember" abstract="true" name="OtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLeaseAssets" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLeaseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_ManufacturingSupportSegmentMember" abstract="true" name="ManufacturingSupportSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_NoveprimGroupMember" abstract="true" name="NoveprimGroupMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_AdjustmentOfRedeemableNoncontrollingInterest" abstract="false" name="AdjustmentOfRedeemableNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_IncreaseDecreaseInContractWithCustomerLiabilityCustomerDeposits" abstract="false" name="IncreaseDecreaseInContractWithCustomerLiabilityCustomerDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_TemporaryEquityOtherComprehensiveIncomeLossNetOfTax" abstract="false" name="TemporaryEquityOtherComprehensiveIncomeLossNetOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_BusinessCombinationRemainingEquityToPurchase" abstract="false" name="BusinessCombinationRemainingEquityToPurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crl_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" abstract="true" name="ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="crl_BusinessCombinationPutOptionTermPeriodAfterFirstAnniversary" abstract="false" name="BusinessCombinationPutOptionTermPeriodAfterFirstAnniversary" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
