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  <xs:element id="crl_SupplierMember" abstract="true" name="SupplierMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_VitalRiverMember" abstract="true" name="VitalRiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_RedeemableNoncontrollingInterestDividendReceivableFairValue" abstract="false" name="RedeemableNoncontrollingInterestDividendReceivableFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_NoncontrollingInterestAdditionalOwnershipPercentageAcquiredByParent" abstract="false" name="NoncontrollingInterestAdditionalOwnershipPercentageAcquiredByParent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_RedeemableNoncontrollingInterestPurchasePricePayable" abstract="false" name="RedeemableNoncontrollingInterestPurchasePricePayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_IncreaseDecreaseInUnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" abstract="false" name="IncreaseDecreaseInUnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_AccruedCompensationMember" abstract="true" name="AccruedCompensationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_SeveranceAndTransitionCostsMember" abstract="true" name="SeveranceAndTransitionCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_AssetImpairmentsMember" abstract="true" name="AssetImpairmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_OtherCostsMember" abstract="true" name="OtherCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_JamesFosterMember" abstract="true" name="JamesFosterMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_BirgitGirshickMember" abstract="true" name="BirgitGirshickMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
