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  <xsd:element id="crl_DeferredCompensationArrangementwithIndividualPeriodofHighestConsecutiveYearsofCompensationUsedforDeterminationofExecutiveSupplementalLifeInsuranceRetirementPlanBenefit" name="DeferredCompensationArrangementwithIndividualPeriodofHighestConsecutiveYearsofCompensationUsedforDeterminationofExecutiveSupplementalLifeInsuranceRetirementPlanBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_DeferredTaxAssetsOperatingLeaseLiability" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_DeferredTaxAssetsOperatingLossAndCreditCarryforwards" name="DeferredTaxAssetsOperatingLossAndCreditCarryforwards" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_DeferredTaxLiabilitiesDeferredExpenseDepreciation" name="DeferredTaxLiabilitiesDeferredExpenseDepreciation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" name="DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_DeferredTaxLiabilitiesTaxCutsAndJobsActOf2017IncompleteAccountingTaxOnUnremittedEarnings" name="DeferredTaxLiabilitiesTaxCutsAndJobsActOf2017IncompleteAccountingTaxOnUnremittedEarnings" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_DeferredTaxLiabilitiesTaxCutsAndJobsActOf2017IncompleteAccountingTaxOnUnremittedEarningsPercent" name="DeferredTaxLiabilitiesTaxCutsAndJobsActOf2017IncompleteAccountingTaxOnUnremittedEarningsPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_DefinedBenefitPlanActuarialGainLossChangeinMortalityAssumptions" name="DefinedBenefitPlanActuarialGainLossChangeinMortalityAssumptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="crl_DefinedBenefitPlanBenefitObligationsAdministrativeExpensesPaid" name="DefinedBenefitPlanBenefitObligationsAdministrativeExpensesPaid" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_DefinedBenefitPlanContributionsByEmployerToParticipantsOutsideOfPlanAssets" name="DefinedBenefitPlanContributionsByEmployerToParticipantsOutsideOfPlanAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_DefinedBenefitPlanIncreaseDecreaseInProjectedBenefitObligationFromChangeInDiscountRate" name="DefinedBenefitPlanIncreaseDecreaseInProjectedBenefitObligationFromChangeInDiscountRate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="crl_DepreciationAndAmortizationExpenseMember" name="DepreciationAndAmortizationExpenseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_DiscoveryandSafetyAssessmentMember" name="DiscoveryandSafetyAssessmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_DisposalGroupIncludingDiscontinuedOperationAssetsExcludingPropertyPlantandEquipmentNoncurrent" name="DisposalGroupIncludingDiscontinuedOperationAssetsExcludingPropertyPlantandEquipmentNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_DisposalGroupIncludingDiscontinuedOperationsWorkingCapital" name="DisposalGroupIncludingDiscontinuedOperationsWorkingCapital" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_EffectiveIncomeTaxRateReconciliationImpactofAcquisitionsPercent" name="EffectiveIncomeTaxRateReconciliationImpactofAcquisitionsPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_EffectiveIncomeTaxRateReconciliationTaxCreditsAndDeductions" name="EffectiveIncomeTaxRateReconciliationTaxCreditsAndDeductions" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_EffectiveIncomeTaxReconciliationTaxCutsAndJobsActOf2017TransitionTaxOnAccumulatedForeignEarningsPercent" name="EffectiveIncomeTaxReconciliationTaxCutsAndJobsActOf2017TransitionTaxOnAccumulatedForeignEarningsPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_EmployeeServiceSharebasedCompensationNonvestedAwardsTotalCompensationCostNotyetRecognizedPeriodforRecognitioninYears" name="EmployeeServiceSharebasedCompensationNonvestedAwardsTotalCompensationCostNotyetRecognizedPeriodforRecognitioninYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_EquityMethodInvestmentIncreaseDecreaseInOwnershipPercentageByParent" name="EquityMethodInvestmentIncreaseDecreaseInOwnershipPercentageByParent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="crl_EquityMethodInvestmentInvestmentCommitment" name="EquityMethodInvestmentInvestmentCommitment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_EquityMethodInvestmentInvestmentCommitmentAmountFunded" name="EquityMethodInvestmentInvestmentCommitmentAmountFunded" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityChangeInPreviouslyRecordedAdjustment" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityChangeInPreviouslyRecordedAdjustment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_FairValueofPensionPlanAssetsTableTextBlock" name="FairValueofPensionPlanAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_FiniteLivedIntangibleAssetsOtherThanCustomerRelationshipsMember" name="FiniteLivedIntangibleAssetsOtherThanCustomerRelationshipsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_HemaCareCorporationMember" name="HemaCareCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_IncreaseDecreaseInContractWithCustomerLiabilityCustomerDeposits" name="IncreaseDecreaseInContractWithCustomerLiabilityCustomerDeposits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_InsurancePoliciesDeductible" name="InsurancePoliciesDeductible" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_InvestmentsinLimitedPartnershipsTextBlock" name="InvestmentsinLimitedPartnershipsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_KWSBioTestLimitedMember" name="KWSBioTestLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_LeaseArrangementsAxis" name="LeaseArrangementsAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_LeaseArrangementsDomain" name="LeaseArrangementsDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_LeasesWeightedAverageDiscountRateAbstract" name="LeasesWeightedAverageDiscountRateAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" name="LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_LineOfCreditFacilityFeesPaidForTemporaryBackstopFacility" name="LineOfCreditFacilityFeesPaidForTemporaryBackstopFacility" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_LongTermDebtAndLeaseObligationNetOfCurrentPortion" name="LongTermDebtAndLeaseObligationNetOfCurrentPortion" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_LongtermDebtGrossAndLeaseObligation" name="LongtermDebtGrossAndLeaseObligation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="crl_MPIResearchMember" name="MPIResearchMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_ManufacturingSupportMember" name="ManufacturingSupportMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_MarketableSecuritiesAndEquityMethodAffiliatesAbstract" name="MarketableSecuritiesAndEquityMethodAffiliatesAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_MaxPsuShares" name="MaxPsuShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="crl_MaximumBorrowingCapacityTermLoanandLineofCreditFacilityPotentialIncreaseAvailable" name="MaximumBorrowingCapacityTermLoanandLineofCreditFacilityPotentialIncreaseAvailable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_NetIncomeLossIncludingPortionAttributabletoNoncontrollingInterestandExcludingRedeemableNoncontrollingInterest" name="NetIncomeLossIncludingPortionAttributabletoNoncontrollingInterestandExcludingRedeemableNoncontrollingInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_NetOperatingLossCarryforwardExpiringNextYearMember" name="NetOperatingLossCarryforwardExpiringNextYearMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_NumberofQuarterlyInstallmentPayments" name="NumberofQuarterlyInstallmentPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="crl_OneBillionFiveHundredAndFiftyMillionCreditFacilityMember" name="OneBillionFiveHundredAndFiftyMillionCreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OneBillionSixHundredAndFiftyMillionCreditFacilityMember" name="OneBillionSixHundredAndFiftyMillionCreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_OperatingLeasesFutureMinimumPaymentsForLeasesNotYetCommenced" name="OperatingLeasesFutureMinimumPaymentsForLeasesNotYetCommenced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="crl_OperatingLossCarryforwardsByExpirationPeriodAxis" name="OperatingLossCarryforwardsByExpirationPeriodAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OperatingLossCarryforwardsByExpirationPeriodDomain" name="OperatingLossCarryforwardsByExpirationPeriodDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OtherAcquisitionsMember" name="OtherAcquisitionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OtherLongTermDebtMember" name="OtherLongTermDebtMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OtherMember" name="OtherMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_OtherPlanAssetCategoriesMember" name="OtherPlanAssetCategoriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_PerformanceSharesGranteeGroupOneMember" name="PerformanceSharesGranteeGroupOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_PerformanceSharesGranteeGroupTwoMember" name="PerformanceSharesGranteeGroupTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_PropertyPlantandEquipmentUsefulLivesTableTextBlock" name="PropertyPlantandEquipmentUsefulLivesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_ResearchModelsAndServicesMember" name="ResearchModelsAndServicesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_RestrictedStockRestrictedStockUnitsandPerformanceShareUnitsMember" name="RestrictedStockRestrictedStockUnitsandPerformanceShareUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_RestrictedStockandRestrictedStockUnitsMember" name="RestrictedStockandRestrictedStockUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_RestructuringReservePaymentsforRestructuringandSettledwithoutCash" name="RestructuringReservePaymentsforRestructuringandSettledwithoutCash" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_SalariesAndBonus" name="SalariesAndBonus" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignAndComponentsOfIncomeTaxExpenseBenefitTableTextBlock" name="ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignAndComponentsOfIncomeTaxExpenseBenefitTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfOtherAssetsCurrentTableTextBlock" name="ScheduleOfOtherAssetsCurrentTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfOtherLiabilitiesCurrentTableTextBlock" name="ScheduleOfOtherLiabilitiesCurrentTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfOtherLiabilitiesNoncurrentTableTextBlock" name="ScheduleOfOtherLiabilitiesNoncurrentTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_ScheduleOfStockRepurchasesTable" name="ScheduleOfStockRepurchasesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfUnallocatedCorporateOverheadTableTextBlock" name="ScheduleOfUnallocatedCorporateOverheadTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_ScheduleOfUnrecognizedTaxBenefitsRollTableTextBlock" name="ScheduleOfUnrecognizedTaxBenefitsRollTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_SeniorNotesDue2026Member" name="SeniorNotesDue2026Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_SeniorNotesDue2028Member" name="SeniorNotesDue2028Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_Sensitivityofchangeinexpectedrateofreturnannualpensionexpenseamount" name="Sensitivityofchangeinexpectedrateofreturnannualpensionexpenseamount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_Sensitivityofexpectedrateofreturnonplanassetspercentchange" name="Sensitivityofexpectedrateofreturnonplanassetspercentchange" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_SeveranceAndTransitionCostsMember" name="SeveranceAndTransitionCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_SharebasedCompensationArrangementbySharebasedPaymentAwardNumberofSharesPerEmployeeAvailabletoPurchase" name="SharebasedCompensationArrangementbySharebasedPaymentAwardNumberofSharesPerEmployeeAvailabletoPurchase" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="crl_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsNumberofSharesEquivalent" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsNumberofSharesEquivalent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="crl_SharebasedCompensationArrangementsbySharebasedPaymentAwardFairValueAssumptionsChangeinWeightedAverageStockPrice" name="SharebasedCompensationArrangementsbySharebasedPaymentAwardFairValueAssumptionsChangeinWeightedAverageStockPrice" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_StockRepurchaseProgramAuthorizedAmountIncreaseDecrease" name="StockRepurchaseProgramAuthorizedAmountIncreaseDecrease" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_StockRepurchasesLineItems" name="StockRepurchasesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_SupplementalBalanceSheetInformationAbstract" name="SupplementalBalanceSheetInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_SupplementalBalanceSheetInformationTextBlock" name="SupplementalBalanceSheetInformationTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_SupplierMember" name="SupplierMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TaxCreditCarryforwardsByExpirationPeriodAxis" name="TaxCreditCarryforwardsByExpirationPeriodAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TaxCreditCarryforwardsByExpirationPeriodDomain" name="TaxCreditCarryforwardsByExpirationPeriodDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TaxCreditCarryforwardsExpirationRange1Member" name="TaxCreditCarryforwardsExpirationRange1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_TemporaryEquityAdjustmentToFairValue" name="TemporaryEquityAdjustmentToFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_TemporaryEquityIncreaseDecreaseToNoncontrollingInterest" name="TemporaryEquityIncreaseDecreaseToNoncontrollingInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_TemporaryEquityModificationsToEquityInterest" name="TemporaryEquityModificationsToEquityInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TotalEquityAttributabletoCommonShareholdersMember" name="TotalEquityAttributabletoCommonShareholdersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_TradeReceivablesFromCustomers" name="TradeReceivablesFromCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="crl_TradingDayAverageStockPriceOnGrantDate" name="TradingDayAverageStockPriceOnGrantDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_TransactionCosts" name="TransactionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_TreasuryStockPolicyPolicyTextBlock" name="TreasuryStockPolicyPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TwoBillionFiftyMillionCreditFacilityMember" name="TwoBillionFiftyMillionCreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TwoBillionThreeHundredMillionCreditFacilityMember" name="TwoBillionThreeHundredMillionCreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_TwoBillionThreeHundredMillionCreditFacilityTermLoanMember" name="TwoBillionThreeHundredMillionCreditFacilityTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="crl_UnallocatedCorporateOverhead" name="UnallocatedCorporateOverhead" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="crl_UnrecordedUnconditionalPurchaseObligationDueYearOneThroughYearThree" name="UnrecordedUnconditionalPurchaseObligationDueYearOneThroughYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="crl_UnrecordedUnconditionalPurchaseObligationDueYearThreeThroughYearFive" name="UnrecordedUnconditionalPurchaseObligationDueYearThreeThroughYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="crl_VitalRiverMember" name="VitalRiverMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="crl_WeightedAverageRemainingLeaseTermAbstract" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
</xsd:schema>
